Clinical Research On "Shenrong" Decoction Attenuating The Toxicity Of Platinum-Based Chemotherapy In Treating Advanced Non-Small-Cell Lung Cancer

Object ivesTo observe the therapeutic efficacy of "ShenRong" decoction for attenuating the toxicity and improving the quality of life (QOL) of platinum-based chemotherapy in treating advanced Non-Small-Cell Lung Cancer(NSCLC).MethodsForty patients with NSCLC, who were scheduled to be treated by at least2cycles of chemotherapy, were enrolled. They were randomized into2groups:20cases in the "ShenRong" decoction pre-treated group and20cases in the "ShenRong" decoction post-treated group.In the pre-treated group,"ShenRong" decoction was given on the first day of the first regimen, continued for10days. Another regimen was only given with chemotherapy. In the post-treated group, chemotherapy was given solely in the first regimen,"ShenRong" decoction was given on the first day of the second regimen for10days.The toxicity and QOL were evaluated and compared by using WHO malignant tumor toxic chemotherapy classification standard, QLQ-C30and FACT-L.ResultThe major toxicity of platinum-based chemotherapy were hemato-toxicity and digestive toxicity. Among40patients, the hemato-toxicity (toxicity on leukocyte and neutrophil) and the digestive toxicity (represented as vomiting) of chemotherapy revealed in the treated stage (the regimen treated with "ShenRong" decoction) were all less than those in the control stage(the regimen without "ShenRong" decoction)(P<0.05).After treatment, the QOL were better than before in both two plans (P<0.05), and the regimen treated with "ShenRong" decoction was better than chemotherapy only(P<0.05).ConelusionFirst,"ShenRong" decoction can decrease the toxicity, relieve the symptoms and improve the QOL of the patients who were treated by platinum-based chemotherapy. Second, it will be better if "ShenRong" decoction is given early. Third,"ShenRong" decoction is safe, effective and acceptable for advanced NSCLC patients, it worth further study and promotion.