The Standard Decotion Of Xiaochaihu Tang

Decotion is one of effective dosimetry that have special effect and can be used to prevent disease.Decotion have obvious clinical efficacy due to its special advantage.But there is no standard of decotion, so this article make a study about standard of Xiaochaihu Tang.Xiaochaihu Tang is one of famous precription in ShangHanLun writed by Mr Cheung in the Eastern Han Dynasty, the original precription include Radix Bupleuri(25g)、Scutellaria baicalensis(9g)、Pinellia ternata(9g),Liquorice(roasted,9g)、Ginger(cut,9g)、Jujube(4values), this precription can harmonize Shaoyang and Rouse,and it is main precription of Shaoyang disease of ShangHan.The research of literature summarize the factor which have influence on decotion qulity,chemical compostion and pharmacological effect of Xiaochaihu Tang of the precreption and the single durg,some formulation of decotion reformation,and at last it make a simple instruction about fingerprint.The index is included the content of extraction, the content of baicalin,fingerprint,relative density to optimize the extracting technology.The factor is included water doses,soaktime,decotion temperature(high heat firstly and then slow fire, slow fire all the way),decotion time,decotion times, decotion instrument(marmite and health-preserving kettle, marmite and stainless steel kettle). There levels of water doses,soaktime,decotion time and decotion times are made sure, high heat firstly and then slow fire is better than slow fire all the way, marmite is better than health-preserving kettle and stainless steel kettle.The best extracion extracting technology is soaking40min,adding lOBei water,decoting40min, decoting3times by orthogonal experiment.This experiment is proved that decotion time and decotion time have significant difference to the content of baicalin and the content of extraction by variance analysis except soaktime and water doses.On the basic of traditon decotion, there levels of water doses,soaktime,decotion time and decotion times are made sure, this article optimize the extracting technology of machine decoction by orthogonal experiment of L9(34).This paper establish the LSP induction heating the little white rabbit model, to compare the fever effect of ginseng, dangshen to Xiaochaihu Tang, through the SPSS16.0statistical software processing, research shows that the ginseng,dangshen medicine radix soup decoction of small white rabbit caused by LSP has obvious antipyretic role, and there is no significant differences between the three groups, and proved the feasibility of the dangshen replace of ginseng. At the same time, this study is about the determination of interferon (IFN-γ) and tumor necrosis factor (TNF-a) in mice serum to ensure the repalcing.This article is made a contrast studies about Xiaochaihu compound granules and Xiaochaihu Tang about fingerprint and5main index(baicalin, baicalein, wogonoside, wogonin, enoxolone) simultaneous determination which can provide a sicentific fact to convice the repalcing Xiaochaihu compound granules of Xiaochaihu Tang.This paper analyze the content of five main index components(baicalin, baicalein, wogonoside, wogonin, enoxolone)and the specific chromatograms of ten batches of Xiaochaihu granules. It is establelished a quantitative and qualitative method. So it provide a scientific fact for the quality control of Xiaochaihu granules on market.This paper provide experimental evidence for the quality control of Xiaochaihu granule by determining the contents of some representative heavy metallic and trace elements (As,Cd,Zn,Fe,Mg,Mn) in Xiaochaihu granule from ten different pharmaceutical enterprises.