| 调肿瘤MYCN mRNA的表达,促进肿瘤细胞凋亡,有望成为神经母细胞瘤治疗的新药物。 MYCN siRNA group. A significant increase of apoptosis cells was observed at MYCNsiRNA group compared with those at control siRNA group.Conclusion：The bone marrow and bone xenograft mouse model can be successfullyestablished by direct local injection of LA-N-5cells and it would be a valuable tool forunderstanding the biology of metastatic neuroblastoma to bone and marrow, andevaluating the efficacy of potential therapeutic agents. MYCN siRNA was highlyconcentrated in neuroblastoma tissue via folate-nanoliposome entrapment afterintravenous injection. It significantly reduced MYCN mRNA expression and inhibitedneuroblastoma cell apoptosis in nude mice, these findings suggest that FR-targetedliposome is an effective vehicle for tumor-targeted siRNA delivery and the liposomeentrapped folate FT-targeted MYCN siRNA could be a novel therapeutic approach forneuroblastoma. |
PDF Full Text Request