The Innate Immunity Effects Of CRP In Infectious Disease

Objective：To investigate the innate immunity effects of serum C-reactive protein (CRP)as the infectious biomarker, through the infections serum CRP, peripheral blood routineand erythrocyte sedimentation rate (ESR) clinical monitoring results analysis.Methods： Retrospectively collected the nearly a year clinical data of pediatrichospitalized children, with clinical manifestations, peripheral blood routine, chest X-ray,and clinical diagnosis and based on its infection pathogens different were divided intofour groups: the bacteria infection group (group A), the virus infection group (group B),the mycoplasma infection group (group C) and the control group (group D) werecollected during the same period for noninfectious diseases hospitalized children ofclinical data. The comparative analysis each group patients when the primary surveyand the after-treatment the serum level of CRP, white blood cell count (WBC), absoluteneutrophil count (ANC) and ESR differences with other biomarkers, and the correlationbetween CRP levels and WBC, ANC or ESR was also analyzed.Results：1. The serum level of CRP, WBC, ANC in group A was higher significantly thangroup B, C and D (P<0.01), the level of CRP, WBC and ANC in group B, C and D hadno significant difference (P>0.05), the results suggests that CRP is increase in bacterialinfection.2. In group A, the positive rate of CRP was96%, and comparison with the positiverate of WBC(67%), ANC(55%), and ESR(78%), whichever in χ2test were significantlydifferent (P<0.01), the results explain that CRP appear earlier and to respond quicklyfor foreign antigen, is superior to other innate immune biomarker.3. The level of CRP in group A of children was obviously reduced after treatmentwith antibiotics, showing significant difference (P<0.01), the results show that throughthe effective anti-infection therapy, the CRP can reflect the body repair process.4. In group A, the correlation test between CRP level and WBC, ANC or ESRcomparison, its related strength from high to low is as follows: WBC>ANC> ESR. Inaddition CRP, the results confirmed the WBC and ANC is still evaluation of bacteriainfection in traditional regular project. 5. In bacteria infection group, the serum level of CRP between the less than3yearsold infant and more than3patients was no significant difference (P>0.05), the resultsexplain that CRP was related with innate immunity.6. In group B, the positive rate of CRP (27%) was slightly higher than the positiverate of WBC and ANC, whichever in χ2test were significantly different (P <0.01), andthe positive rate of CRP and ESR comparison, the difference was no significant (P>0.05), the results indicate that although CRP part rise in the virus infection, butincreased is not significant, this results probably reflection that CRP and tissue damagewas caused by virus infection, and repair has still certain immune significance.7. In the group A, B and D, comparison with the primary survey time for childrencome to the hospital, showing no significant difference (P>0.05), and the three groupscomparison with the group C, the difference was significant (P<0.01), the resultsexplain that the diagnosis of clinic mycoplasma infection is difficulties in the early.8. The level of ESR in group A was higher significantly than group B and D (P<0.01), but compared ESR between group A and C, the difference was no significant (P>0.05), the results suggests that the immunity of erythrocyte have effect in bacterialand mycoplasma infection.9. In group C, the positive rate of CRP was41%, comparison with the positive rateof WBC(18%) and ANC(12%), whichever in χ2test were no significantly difference (P>0.05), and the positive rate of CRP and ESR comparison, the difference wassignificant (P<0.01). At this time the ESR increased obviously, more reflect thefunction of innate erythrocyte immune in mycoplasma infection, and the role of CRPfor mycoplasma infection diagnosis without obvious function.Conclusion: CRP as an important part for innate immunity, and acquired immuneirrelevant, bacterial infection on foreign antigen to respond quickly and appeared earlier,is superior to other innate immunity biomarks, and in effective anti-infection therapy,the CRP biomarker dropped rapidly, can influence the repair process, can be used asearly infection biomark and judgment infection of the severity of sensitive indicators.Early diagnosis of mycoplasma infection is difficult, and erythrocyte immune influencefor the bacteria and mycoplasma infection. Therefore, in pediatric infectious diseases,through CRP dynamic observation, jointing test serum WBC, ANC and ESR, can forclinical early differentiation bacterial infections and other infections, treatment provideeffective guidance to reasonable basis, timely use anti-infection drugs and judgmentcurative effect.