Retrospective Analysis Of51Cases With Severe Drug Eruption In Children

Objective: To study the clinical manifestations and provide the basisfor early recognition and initial management of severe drug erupon inchildren.Methods:.This retrospective analysis was carried out on the clinicaldata of all hospitalized patients in our hospital with severe drug eruptionfrom January2007to December2011, consisting of age, sex,etiology, thesuspicious drugs exposure, clinical feature, incubation period,course，treatment and prognosis.Results:1. In this study, the ratio of hospitalized children with SCADRs inadmission rate is0.22‰. The annual ratio of this five years were0.13‰,0.22‰,0.24‰,0.18‰, and0.31‰respectively, overall showed growthtendency.2. The common clinical tapes in children with SCADRs wereSJS(54.9%)，TEN(27.5%), ED(9.80%)，DHS(7.85%).3. The peak onset age in our cases were1-3years old and6-9yearsold， while it was rare in infants and adolescents.4. The incubation period of both ED and DHS were longer than that of SJS and TEN, but there was no significant difference between ED andDHS.5.The major allergenic drugs were antibiotics (39.21%), NSAIDs(21.57%) and anticonvulsants (17.65%). And the incubation period ofanticonvulsants was longer than that of antibiotics and NSAIDs.6. Infectious diseases (56.86%) were the most important basic diseasesin children with SCADRs.7. Visceral involvement included liver, and then kidney and lung，heartwas rare in our study. Mucous membrane involving was more serious inSJS and TEN.8. The factors related to the prognosis in Children with severe drugeruption were visceral involvement, mucosal involvement and virusinfection.Conclusions: According to the suspicious drugs exposure, allergichistory, clinical lesions, incubation period and other clinicalcharacteristics.The children with SCADRs can be diagnosed and treatedpromptly. Treatment of severe drug eruption includes the rapid withdrawalof the suspicious drugs exposure,use of systemic corticosteroid and/orIVIG as soon as possible,and other support treatment. As a result，earlydiagnosis and processes，are able to decrease mortality rate，increasethe cure rate.