Association Of Asp327asn Polymorphism In The Sex Hormone-Binding Globulin Gene With Type2Diabetes Mellitus In Chinese Han Population

Objective To investigate the association of a common functionalpolymorphism (Asp327Asn) in the sex hormone-binding globulin (SHBG）gene with type2diabetes mellitus (T2DM) in Chinese Han population.Methods Asp327Asn polymorphism in248cases (T2DM group)and351controls (NC group) were genotyped by polymerase chainreaction-restriction fragment length polymorphism (PCR-RFLP) technique.Homeostatic model assessment (HOMA) was used to assess beta cellfunction (HOMA-B) and insulin resistance (HOMA-IR).Results The variant Asn allele frequency was significantly lower inT2DM group than (14.5％,20.1％,respectively) that in NC group.Unconditional logistic regression analysis showed that the variant Asnallele was associated with a reduced risk of T2DM (OR=0.62，95％CI:0.42-0.91，P=0.016)．Conclusion This study suggests that the Asn allele in the SHBG gene might be related to a reduced risk of T2DM in the Chinese Hanpopulation.