Expression Changes Of EGFR And HER2in Paired Primary And Recurrent Astrocytic Tumours

ObjectiveHER family plays an important regulatory role in the process of cell physiology. If EGFR or HER2signal pathway are enabled, it will cause a lot of cell activity change, including cell survival state, cell division and cells to move ability. Previous studies showed that the expression of EGFR and HER2respectively plays important roles in the evolution process of the astrocytic tumours. The purpose of this study is to investigate whether EGFR and HER2are differentially expressed in paired primary and recurrent astrocytic tumours.Methods24patients suffering from recurrent astrocytic tumors with complete clinical data who received two surgical removal in Shandong Provincial Hospital between2003Jan and2010Apr were selected. In addition, we also collect the patient’s clinical factors: gender, age, tumor level, no symptoms of survival and the first postoperative radiotherapy and chemotherapy. The protein expressions of EGFR and HER2were investigated by SABC immunohistochemistry and correlated with clinical treatment factors.ResultsDecreased EGFR (P=0.002) and increased HER2(P=0.006) expression were observed in recurrent astrocytic tumours compared with primary astrocytic tumours. In primary astrocytic tumours, increased EGFR expression had positive correlation with longer progression-free survival (Spearman rank correlation coefficient r=0.441, P=0.031). And in recurrent astrocytic tumours, increased EGFR expression had a correlation with radiotherapy (Spearman rank correlation coefficient r=0.446, P=0.029) and increased HER2expression had a correlation with chemotherapy (r=0.438, P=0.032).ConclusionExpressions of EGFR and HER2are different in paired primary and recurrent astrocytic tumours and have correlation with postoperative treatment factors. In a recurrent astrocytic tumours of EGFR expression is reduced, HER2expression was increased. And high expression of EGFR and asymptomatic patients survival in primary astrocytic tumours are related to. In recurrent astrocytic tumours, high expression of EGFR and radiation have significant correlation, high expression of HER2and chemotherapy are positive correlated.