The Analysis Of X-ray Peroxide Damage In Interventional Operation Of Pediatric Congenital Heart Disease

Objective：To explore the lipid peroxidation damage caused by the X-ray radiation andanti-oxidative active substance in intervention on pediatric patients with congenital heartdisease.To observe whether the damage caused by the X-ray radiation or clinical indicatorsare of relevance.Methods：Sixty-seven cases of pediatric congenital heart disease accepting cardiovascularinterventional treatment were collected randomly from June2010to August2011in ourhospital by clinical examination, X-ray chest, ECG and color Doppler ultrasound diagnosis.There were not viral infection and heavy smoking drinkers. Digital subtraction angiography(DSA) machine was accepted to monitor the value of the interventional reference point at theskin surface incident dose value (cumulative dose, CD). The levels of serum superoxidedismutase (SOD) and malondialdehyde were detected at2hours before and afterinterventional operation separately. T test was used in disease-free interval between the twogroups and P<0.05was considered statistically significant.Results：Serum level of SOD at2hours after operation[(114.3±14.7) U/ml] is lower thanbefore operation [(133.6±18.6) U/ml]（t=7.121, P<0.01）, while serum level of MDA at2hourafter operation[(3.5±1.0) μmol/ml] is higher than before operation [(3.1±1.0) μmol/ml]（t=6.881, P<0.01）. With the radiation doses increasing, SOD level had a gradual decline trendwhich displayed a significant negative correlation(r=-0.68, P<0.05), while MDA level had agradual rise trend which displayed a significant positive correlation(r=0.75, P<0.05). Conclusion：X-ray radiation of interventional therapy may cause an excess of oxygen freeradical in pediatric patients with congenital heart disease, which could cause anti-oxidativesystem disorders and health damages in pediatric patients.