Preparation Of The Ligustrazme Hydrochloirde Sustained-Release Dropping Pills And Investigation Of Its Quality

Objective To prepare the Ligustrazme Hydrochloride sustained-release dropping pills andinvest its quality and in vitro release behavior.Methods single factor experiment and orthogonal design was employed to investigatethe preparation,the former used roundness and tailed degree as index.;Temperature ofdosage liquor，proportion of drugs and groundmass，proportion of PEG6000and stearicacid were used as investigation factors,the roundness，tailed degree and the release rate ofpills as index in orthogonal design to optimize the preparation technology.The identification of Ligustrazme Hydrochloride and the measurement of LigustrazmeHydrochloride in the preparation were be made with the TLC and HPLC respectively．Itsrelease characteristics were studied by rotating basket.Result the optimum technology:PEG6000: stearic is4:1;the proportion of drugs andgroundmass is1:3;the Temperature of dosage liquor is70℃; condensation Temperature is30℃⁰℃.dropping rate is45d·min^-1; dropping distance is5cm.the LigustrazmeHydrochloride sustained-release dropping pills prepared by this method were In line withthe Pharmacopoeia.the release rate is Slowing.The pills’ release process proved to fitHiguchi equation.Conclusion The result of the study proves that the preparation process of thesustained-release dropping pills is stable and the quality of the pills is controllable.theLigustrazme Hydrochloride sustained-release dropping pills has the advantage ofsustained-release effect.