| Background and PurposesOral cancer has become an issue that drawing more and more attention worldwide. Taking oral cancer and pharyngeal as a whole, it has become the sixth most-commonly-happened cancer. It is commonly known that Oral Submucous Fibrosis(OSF) can be deemed as pre-cancer state, or pre-cancer pathological change, which has the potential to lead to cancer disease. Hunan suffers a high incidence rate of OSF, with7-13%of it would lead to cancer and the rate is still going up. Many causes lead to the malignant transformation of OSF, this study applies case-control method, focus on the differences in characteristics of Social demography and lifestyle behaviors of OSF patients and malignant transformation of OSF patients, analyses the risk factors of OSF, supply bases of precaution of malignant transformation of OSF.MethodsTake80cases of OSCC combine with OSF patients in Xiangya hospital, Central South University in the period between2011.1to2011.12, and in comparison, take another80cases of OSF patients with no OSCC at the same place with the same time period. By applying the case-control method, study the differences in characteristics of Social demography and lifestyle behaviors; and to make numeral analysis, SPSS19.0software is introduced to build the database, with P<0.05as statistical significanceResults1. By using the single factor analysis method, factors of old-aged, low-level of education, behavior of smoking, drinking alcohol, drinking spirit, combination of OLK or OLP may lead to the risk of malignant transformation of OSF (P<0.05); holding cigarettes in mouth and the degree of mouth opening has little statistical significance (P>0.05).2. By using chi-square test, the intake amount and the length of time exposing to the betel quid, tobacco and alcohol has a dose-dependent relation with malignant transformation of OSF, the tendency has statistical significance (P<0.05).3. Applying Mantel-Haenszel test, the length of time in chewing betel quid and the frequency of everyday betel quid intake, smoking and drinking alcohol has statistical significance (P<0.05) with malignant transformation of OSF, as illustrated in chart3.5.1. the merge OLK or OLP has little statistical significance (P>0.05).4. Smoking and drinking alcohol will encourage the happen of malignant transformation of OSF, and the combination of two factors has greater effect of each of factors working alone.5. Under Multi-factor Logistic Regression Analysis, old-aged (OR=2.837), long time of betel quid chewing(OR=1.745), large amount of betel quid intake (OR=2.097), large amount of tobacco smoking(OR=1.992), a long history of drinking alcohol(OR=2.434), are factors that could lead to the malignant transformation of OSF.Conclusions1. Old-aged, long time of betel quid chewing, large amount of daily betel quid intake, a long history of drinking alcohol may lead to malignant transformation of OSF.2. The length of time and the amount exposing to betel quid, tobacco and alcohol has a dose-dependent relationship with malignant transformation of OSF. The larger amount and longer time of exposure introduced, the higher risk of cancer will emerge.3. Smoking and drinking alcohol will encourage the occurrence of malignant transformation of OSF, when two factors working together, the effect would be greater than each of factors working alone... |
