Affective Factors Analysis Of Surgical Operation On Hepatitis B Virus Reactivation

Objective:(1) To study the infection and epidemiology of hepatitis B virus (HBV) from the patients with surgical operation.(2) To investigate the HBV reactivation caused by surgical operation-induced immunosuppression and its affective factors analysis.(3) To assay the effect of HBV reactivation on liver function.Methods:(1) The retrospective analysis of blood transfusion-语related infectious diseases test of5898surgical operation patients (inpatients from March2010to March2011) was performed.(2) Sixty cases of surgical operation with HBV infection were selected. The preoperative analysis of HBV-DNA, ALT, serological markers of hepatitis B virus, and at1weeks postoperative monitoring of HBV-DNA and serum marker changes were performed.(3) The60patients in preoperative, postoperative lday,3day,7day, even following the detection of ALT, AST, TBIL, DBIL, analysis of its trend were studied. All the results obtained by SPSS13.0statistical analysis software was compared using analysis of variance; measurement data using t detection; count data using X2test; analysis of risk factors using a multivariate Logistic regression analysis; liver function injury using repeated-measures analysis of variance.Results:(1) The HBsAg positive rate of surgical operation patients was10.35%, of which40to60years of age HBsAg positive rate was the highest; farmer, operation history, history of blood transfusion in patients with HBsAg carrying rate and other occupation, without operation history, a history of blood transfusion and the difference between.(2)19cases in60patients with chronic hepatitis B virus infection (31.7%) were activated,41cases (68.3%) the virus inactive; single factor analysis in hepatitis B carriers of gender, HBeAg and HBV-DNA viral load of HBV activation effect, P=0.048, P=0.036, P=0.001; a plurality Logistic regression analysis showed that operation trauma, blood transfusion is the activation of HBV risk factors, the OR values were4.671,3.818.(3)60cases of virus carriers after ALT, AST, TBIL value increased and operation before significant differences exist, after7days back to the preoperative level.Conclusion:Surgical operation and the stress response caused by host immune function inhibition can result in activation of hepatitis B virus replication. The HBV-DNA assay is a good indicator of response to virus reactivation. The effect of virus activation after operation on liver function is not significant in short period, long-term follow-up observation should be further studied.