The Joint Inhibitory Effects Of The Combinantion Of Emodin And Meropenem And(or)Amikacin On MRPA

Objective:to observe the joint in-vitro inhibitory effects of the combinantion of emodin and meropenem and (or) amikacin on Multi-resistant pseudomonas aeruginosa (MRPA), provide experimental basis for the clinical treatment of multiple drug-resistant pseudomonas aeruginosa iatrogenic infection, guide clinical rational drug use, reduce the generation of pseudomonas aeruginosa resistance, and improve the antimicrobial effect.Methods:356strains of MRPA were selected、seperated and cultured as the research objects from March2010to June2011. The anlysis of the clinical infection characteristics and the drug sensitive test were carried out. The research objects were divided into seven groups, and the data were statistically analyzed by using SPSS13.0Results:Minimum inhibition concentration (mic)(MIC50), minimum inhibition concentration (mic)(MIC90) and minimum bactericidal concentration (MBC) of the combination of emodinand meropenem (or amikacin) showed statistically difference (P<0.05) when compared with meropenem or amikacin.Conclusion:The combinantion of emodin and meropenem (or amikacin)can improve the antibiotic sensitivity to MRPA and effectively reduce the effective antibacterial concentrations and bactericidal concentrations of amikacin and meropenem. Emodin plays an important auxiliary role in the antimicrobial therapy of MRPA.