Investigation Of The Prevalenceand And Related Factors Of Cholelithiasis In Elderly Of Nanning Health Examination Population

Objective:Investigate the prevalence and the related factors ofcholelithiasis in the elderly population of Nanning health examinationpopulation,clear the prevalence and risk factors of cholelithiasis in the elderlypopulation of Nanning health examination population, and to provide scientificbasis for the prevention and treatment of the elderly cholelithiasis。Method:1.The objects of investigate were the crowd of2257people aged60yearsand over health examination in health examination ceter of People’s Hospital ofGuangxi in2011.2.The content of investigation include general information,physical,surgicaland related routine examination, liver function, blood lipids,blood glucose andother biochemical indicators of inspection, and ultrasonography of the liver andbiliary system.3.The main indicators of investigation include the prevalence ofcholelithiasis and related diseases in this population, such as diabetes, fatty liver,hyperlipidemia, hypertension, and characteristics and related factors of cholelithiasis in the population.4.Statistical analysis of the all data by using SPSS for windows17.0statistical software. The prevalence rate of disease expressed as a percentage anduses χ~2Test to analysis. The measurement data expressed as the mean value±standard deviation (x s)and analyzed by t-test. The risk factors wereanalyzed by univariate and dichotomous logistic regression analysis. Theinspection level of test α=0.05, P <0.01is considered the significant difference,P <0.05is considered difference.Result:1.The number of cholelithiasis, diabetes, hyperglycemia, fatty liver,Hyperlipidemia and hypertension were respectively281,285,314,896,1428and1180in the elderly population of Nanning, the prevalence rates were12.5%,12.6%,13.9%,39.7%,63.3%and52.3%correspondingly.2.The total prevalence of cholelithiasis was12.5%in the elderlypopulation，male8.2%，female18.2%, the prevalence rate of cholelithiasis infemales significantly higher than males(p<0.01).The prevalence of cholelithiasisof women was significantly higher than men in each age group (p<0.01). Theprevalence of cholelithiasis in female have shown an increase trend with the ageincreasing (p<0.05), the prevalence of cholelithiasis of male was no differencein each age group (p>0.05).3. The prevalence of cholelithiasis in hyperlipidemia population wassignificantly higher than normal lipid population(p<0.01),the prevalence ofcholelithiasis of female was significantly higher than male in hyperlipidemiapopulation(p<0.01).The prevalence of cholelithiasis in different types ofhyperlipidemia crowd was higher than normal lipid groups, and the prevalenceof cholelithiasis in hypercholesterolemia and mixed hyperlipidemia population compared with normallipid groups was significantly different(p<0.01,p<0.05).4. The prevalence of cholelithiasis in the diabetic and hyperglycemicpopulation were significantly higher than the normal blood sugarpopulation(p<0.01), the prevalence of cholelithiasis of female was significantlyhigher than male in diabetic and hyperglycemic population (p<0.01), theprevalence of cholelithiasis in diabetic population was significantly higher thanthe normal blood sugar population in female crowd. The prevalence ofcholelithiasis of male was no difference in different blood glucose level(p>0.05).5. The prevalence of cholelithiasis in fatty liver population wassignificantly higher than non-fatty liver population (p<0.01), the prevalence ofcholelithiasis of female was significantly higher than male in fatty liverpopulation (p<0.01). The prevalence of cholelithiasis of fatty liver populationwas significantly higher than non-fatty liver population in female population(p<0.01).In male population, the prevalence of cholelithiasis in fatty liverpopulation compared with non-fatty liver population was no difference (p>0.05).6. Univariate analysis showed, the age, fasting glucose, total cholesterol,triglyceride, ALT and AST in the cholelithiasis group were significantly higherthan the non-cholelithiasis group (P<0.05), the high-density lipoprotein levelwas lower in the cholelithiasis group (P<0.05). The prevalence rates of highblood sugar, diabetic, hyperlipidemia, fatty liver, hypertension, and abnormal ofALT/AST in the cholelithiasis group were significantly higher than thenon-cholelithiasisgroup (P<0.05).7. The dichotomous Logistic regression analysis showed, the six indicatorsof gender, age, diabetes, hyperlipidemia, fatty liver and high-density lipoproteinwere closely related to cholelithiasis. Conclusion:1.In the elderly in the physical examination population of Nanning,therewere very high prevalence of cholelithiasis, hyperlipidemia, diabetes, fatty liverand hypertension,there was higher prevalence of cholelithiasis in hyperlipemia,diabetic and fatty liver population.2.The prevalence of cholelithiasis in the elderly in the physical examinationpopulation of Nanning was closely correlate with age and sex, and hyslipidemia,diabetes, fatty liver were the important factors which can affect the prevalenceof cholelithiasis.3. Active prevention and treatment of dyslipidemia, diabetes, fatty liverdisease in the elderly populatin, improving dietary structure and controlingblood glucose and blood lipid level, for the prevention of cholelithiasis in theelderly population has important significance.