The Aspartate Aminotransferase To Platelet Ratio Index For Prediction Of Pathological Status Of Liver In Patient With Chronic Hepatitis B

Objective To explore the aspartate aminotransferase to platelet ratioindex(APRI) and alanine aminotransferase to platelet ratio index (BPRI) forprediction of pathological status of liver in patients with chronic hepatitis B.Methods167consecutive patients with chronic hepatitis B wereretrospectively studied, The pathological grading and staging of the liver biopsyspecimens were assessed.The liver function and blood routine weretestet,SPSS13.0for statistic analysis.Independent-Samples T Test was used forcomparisons of APRI、 BPRI among different pathological grading andstaging,Spearman’s rank correlation coefficient was used for rank correlationanalysis, Receiver operating characteristic(ROC)curve was used to predict thediferent pathological grading and staging.Results1.APRI, BPRI were positively correlated with liver tissuepathology classification and stage（r=0.434、0.430and0.327、0.252,P <0.01）.2.There were significant differences in APRI between G1and G2、G3,G0-1andG2-4（P<0.05）,and there were no significant differences in the othergrading(P>0.05).3.In BPRI there were significant differences between G0and G4,G1and G2,G0-1and G2-4(P<0.05), and no significant differences in theother grading.4.there were significant differences in APRI、BPRI between S2and S3(P<0.05), and no significant differences in the otherstaging(P>0.05).5.The area under ROC curve of APRI and BPRI forprediction of G2to G4were0.748、0.736，(95％CI:0.669-0.827、0.653-0.819，P0．000and0．000)；and the optimal cut-off value of which were0.601、0.630,Taking APRI≥0.601and BPRI≥0.630for prediction of G2to G4,thesensitivity，specificity，Youden index were63.6%and82.7%，74.5%and59.6%，39%and42.4%.Conclusions1.APRI、 BPRI could used to predict the hepatitis Bassociated inflammatory activity and fibrosis.2.APRI、BPRI could predict thechronic hepatitis B evident inflammatory activity (G2to4).3.APRI、BPRI couldnot predict the evident fibrosis(S2to4).