Relationship Between HsCRP And ALT Of T2DM With NAFLD

Background: High sensitive C reactive protein (hsCRP) is an easilymeasured marker of systemic inflammation.In recent years. The hsCRPlevel was reported to increase in type2diabetes mellitus (T2DM) withnon-alcoholic fatty liver disease (NAFLD) and found that hsCRP playedan important role in the pathogenesis of T2DM with NAFLD. However,whether hsCRP is involved in its development was rarely investigatedpreviously. So we analyze the relationship between hsCRP and alanineaminotransferase(ALT) to explore the interrelationships between chronicinflammation and the pathogenesis and progression of type2diabetesassociated with nonalcoholic fatty liver disease.Objective: This study aims to investigate the relationship betweenserum highly sensitive C reactive protein (hsCRP) and alanineaminotransferase (ALT) in type2diabetes with nonalcoholic fatty liverdisease.Method:168cases of T2DM patients divided into two groups: type2 diabetes with nonalcoholic fatty liver group (66cases), type2diabeteswithout nonalcoholic fatty liver group (102cases). Blood lipids,hemoglobin, white blood cell, hsCRP, ALT and abdominal B ultrasoundand other index are mensured.Results: Age，BMI，DBP, TC, TG, hsCRP, WBC, ALT levelsincreased significantly (P <0.05) in NAFLD group than that in controlgroup, while HDL-C is significantly reduced (P <0.01). Results of logisticanalysis shows that hsCRP is a risk factor for NAFLD with T2DM (OR=1.613, P <0.01). Linear correlation analysis shows that hsCRP level ispositively correlated with ALT (r=0.220, P <0.01).Conclusion:The increasing of ALT in nonalcoholic fatty liver diseasewith type2diabetes mellitus (T2DM) patients is closely related to hsCRP,hsCRP plays an important role in occurrence and development of type2diabetes with nonalcoholic fatty liver disease.