Primary Study On Changes Of Renal Functions In Neonates Born To Gestational Diabetes Mellitus Mothers

Background and Objective:Gestational diabetes mellitus(GDM) is the disease of different degree glucose metablism disorders which first occurrence or found in pregnance. As a complex metabolic disorder disease, it has serious impact on pregnant mother and fetal, especially making children a series of long-term complication. Manyorgans functions obstacles were caused by gestational diabetes to infants of diabetic mother, including the nervous system, heart function, respiratory system and skeletal system and so on. And these would cause serious bad effections for long term lives quality of children. As the perinatal continuing medical research and progress, although diabetes children’s research were more and more extensive, but there was few of investigation on renal functions of GDM neonates domestic and overseas. To primary investigate the changes of renal functions in neonates born to GDM, according to observing the levels of cystatin C、β2-microglobuLin、Blood urea nitrogen、Creatinine, increase awareness of the complication of the neonates born to GDM, and promove the quality of life.The patients and the Methods1. The patientsAll the cases involved in this study were neonates born in Shandong University Affiliated Provincial Hospital, whose mother had GDM.45neonates born by GDM mothers were enrolled into the experimental group, including23boys,22girls,25cases of premature infants,20cases of term infants,20cases of the macrosomia,25cases of newborns whose birth weight less or equal to4kilograms. the control group included45healthy neonates born in the same period as the experimental group, consisted of21boys,24girls,18cases of premature infants,27cases of term infants,22cases of the macrosomia,23cases of newborns whose birth weight less or equal to4kilograms. There were no difference of gender in the experimental group and control group. All the patients have no diseases of impact on glucose metabolism and renal functions, such as serious infection, hyperbilirubinemia, asphyxia, hypoxic-ischemic encephalopathy (HIE), and excluding organic double kidney diseases.2. MethodsFasting peripheral blood test were conducted to measure Levels of cystatin C(Cys-C),β2-microgLobuLin(β2-MG),Blood urea nitrogen (BUN) and Creatinine (CREA) within72hours after birth by Automatic biochemical analyzer type OLYMPUS-AU5400made in Guangzhou. Data were analyzed between experimental and control groups.Results1.Compared with the control group, neither BUN nor CREA levels had no significant change in the experimental group. Levels of Cys-C and β2-MG increased significantly in the experiment group (P<0.05)2.Both the premature infants and the term infants born to GDM, the levels of Cys-C and β2-MG were higher than the control group (P<0.05). Compared with the control group, both the macrosomia and the normal birth weight infants, the Cys-C and β2-MG increased in the experimental group (P<0.05)3.There was no significant difference between the macrosomia and the normal birth weight infants (P>0.05). Also no significant difference was found between the premature infants and the term infants in the experiment group (P>0.05)Conclusion1. Cys-C and P2-MG Levels in neonates with gestational diabetes mellitus mothers were higher than those with normal mothers, then we can predict that there was renal damage in neonates born by gestational diabetes mellitus mothers. 2The damage of renal function in GDM neonates was no obvious relevant with the weight and gestational age.