| BACKGROUND:The incidence of bronchiectasis in developing countrie s is increasing year by year, and gradually affects the mortality of major dise ases. Its underestimation of the epidemic in developing countries is becoming a common problem.OBJECTIVE:Data analysis of collected clinical data, and analysis of cl inical manifestations of the local bronchiectasis and laboratory examinations, i n order to deepen understanding of the bronchodilator and provide help to de al with bronchiectasis.METHODS:Collate five general hospitals of Shandong’s285cases, fro m January2006to February2012, who confirmed by high-resolution CT or CT of bronchiectasis patients medical records. Compare the difference before and after the admission of acute exacerbation of the treatment process as well as other relevant data. Self-designed database bronchiectasis patients with per sonal follow-up medical records, follow-up the stability of the disease and int ervention by phone or appointment of experts outpatient.RESULTS:1. Mean age of participants (42.5%males,57.5%females) was55.26±15.05years and22.5%of them have of smoking history. Body mass index w as21.12±4.92.2. Most common identified causes of bronchiectasis were idiopathic (205/285,71.9%), after infection disease (except tuberculosis,45/285,15.8%), tuberc ulosis (31/285,10.9%), Kartagener Syndrome (2/285,0.7%), allergic bronchop ulmonary aspergillosis (1/285,0.4%) and immunodeficiency (1/285,0.4%), cys tic fibrosis, no cases caused by cystic fibrosis lung, alpha1antitrypsin deficie ncy or inflammatory bowel disease (IBD)3. The main symptoms are chronic cough (77.2%), cough purulent sputu m (67.7%), shortness of breath (46.7%) and hemoptysis (33.7%). the lungmay auscultate with wheezes (usually49.5%, acute episode67.4%), rales or rhonc hi (usually27.7%, acute episode50.9%).4. There are three types of bronchiectasis, columnar (64285,22.5%), cur ve (39/285,13.7%), cystic(57/285,20.0%) and mixed type(125/285,43.9%).71.9%of patients are three or more lung lobe destruct, and61.8%are bilateral.5. In the routine pulmonary function tests in112patients,39.3%of the m with normal lung function.38.4%are obstructive ventilation function obsta cle, and10.7%are restrictive, with11.6%mixed abnormal lung function. Bro nchiectasis with Cystic type may have more risk for lung function abnormal.6. According to the repeated sputum culture and drug sensitivity results, bronchiectasis patients with the most common pathogen were Pseudomonas aer uginosa(73.5%), Escherichia coli(8.2%), staphylococcus(1.9%), enterococcus(0.5%), Acinetobacter baumannii(3.8%), candidiasis(4.9%), Aspergillus(6.2%), Myc obacterium tuberculosis(1.4%). A small amount of cases, colonization of patho genie fungus, and the positive rate of G/GM test was2/6(33.3%) and3/16(18.8%). CONCLUSION:The performance of the Shandong’s bronchiectasis patie nts are generally repeated coughing and expectoration, hemoptysis, chest tightn ess shortness of breath and stubborn pulmonary rales. Most of the cases did not find the potential etiologies, considered as idiopathic bronchiectasis. Bron chial destruction after inflammation is the main pathological process. Cystic br onchiectasis patients’clinical manifestation and pulmonary function injury may be more serious than other patients. Pseudomonas aeruginosa can be long-ter m colonization in patients’lung, difficult to remove. In the acute stage, the G test and GM test’s result can guide the application of antibacterial drugs’a pplication in some patients. |
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