Statin Use And Development Of Atrial Fibrillation In Patients Underwent CABG:a Meta-analysis Of Randomized Clinical Trials And Observational Studies

Background:Some clinical trials have demonstrated that preoperative statin therapy may have role in preventing atrial fibrillation (AF) in patients underwent CABG, but relevant trials are insufficient.Objective:The purpose of this paper was to investigate the effect of preoperative statin therapy on the prevention of atrial fibrillation in patients underwent CABG.Methods:1、Searching the electronic databases from inception to Dec.10th2011for published trials that assessed the effect of statins therapy on atrial fibrillation in patients after CABG.2、Evaluating the quality of the trails by the title and abstract of the literature (according to the Jadad standard)3、Extracting relevant data from the trails.4、Conducting the meta-analysis of the data collected from the included studies with the soft of review manager5.1,and calculating the basis of strict quality evaluation on studies of RCT.Results:After searching,6RCT studies including1392Patients were chosen to evaluate the efficacy of statin therapy. The test for heterogeneity in all included studies was significant. A random effects model of Meta-analysis was conducted. Compared with placebo or no statins treatment, the difference in pooled efficacy of statins is significant:the total Relative Risk (RR) was0.53,95%confidence interval (CI) was0.44-0.64, test for overall effect:Z=6.50,P<0.00001. Sensitivity analysis suggested that the results have a good reliability. No significant publication bias has been found.Conclusion:We conclude that statin administration results in a reduction in the incidence of atrial fibrillation in patients who undergo cardiac surgery. But more large-scale, multicenter, prospective RCTs are needed to confirm this conclusion.