Research On Relationship Between The TCM Syndromes Of Chronic Atrophic Gastritis And Helicobacter Pylori Infection

Objective:By investigating the distribution of chronic atrophic gastritis(CAG), the thesis aims to summarize the relationship between syndromes types distribution of chronic atrophic gastritis (CAG) and Helicobacter Pylori infection, and analyze its regularity with the view to guiding clinical treatment.Methods:By means of question investigation of epidemiology on the basis of literature study,150patients with CAG are gathered while database is established. They are categorized into five syndrome types, namely, syndrome of incoordination between liver and stomach, weakness of spleen and stomach, syndrome of dampness heat of spleen and stomach, syndrome of yin deficiency of stomach and syndrome of stasis in stomach collateral. Adopting the methods of descriptive statistics, chi-square test and Fisher’s exact probability, the thesis is to analyze the correlation between various syndromes and Hp infection, atrophy, intestinal metaplasia and dysplasia.Results:1. The frequency of TCM syndromes types in descending order is: syndrome of incoordination between liver and stomach (32.7%)>syndrome of weakness of spleen and stomach (22.0%)> syndrome of dampness heat of spleen and stomach(21.3%)>syndrome of yin deficiency of stomach (18.7%)> syndrome of stasis in stomach collateral(5.3%).2. CAG patients with different syndromes have varying degrees of Helicobacter Pylori infection:syndrome of dampness heat of spleen and stomach(78.1%)>syndrome of yin deficiency of stomach (75.0%)>syndrome of weakness of spleen and stomach (51.5%)> syndrome of stasis in stomach collateral(50.0%)> syndrome of incoordination between liver and stomach (49.0%). There are significant statistical differences among all the groups on the basis of the positive rate of Helicobacter pylori infection by Fisher’s Exact Test, p<0.05.3. Different syndromes of patients with CAG have different degrees of dysplasia:syndrome of stasis in stomach collateral (75.0%)> syndrome of yin deficiency of stomach (42.9%)> syndrome of dampness heat of spleen and stomach (18.7%)> syndrome of weakness of spleen and stomach (18.2%)> syndrome of incoordination between liver and stomach (12.2%). There are significant statistical differences among all the groups on the basis of the positive rate of H.pylori infection by Fisher’s Exact Test, p<0.05.4. The comparison between the degrees of glandular atrophy and intestinal metaplasia among TCM syndrome groups shows no difference in statistics.5. The comparison between the degrees of Hp infection and glandular atrophy, intestinal metaplasia and dysplasia among TCM syndrome groups shows no difference in statistics.Conclusion.1. CAG patients with different syndrome types have different Hp infection rates:dampness heat of spleen and stomach was the highest, followed by the stomach yin deficiency group, weakness of the spleen and stomach, the stomach meridian stasis group and incoordination between liver and stomach.2. CAG patients with different syndrome types have different degrees of dysplasia:the highest dysplasia positive rate belonged to the stomach meridian stasis group, followed by the stomach yin deficiency, dampness heat of spleen and stomach, weakness of the spleen and stomach, with the last one being incoordination between liver and stomach.