| Objective Unilateral spatial neglect (USN), a kind of severe cognitive disordersespecially in the attentioanl system, usually follow the stroke. And such attentionaldisorders affects the quality of life and the rehabilitation seriously. With detecting USNpatients timely and testing their attentional bias correctly, the threatment of USN willobtain better effect. Meanwhile, the study of attentional bias in USN patients cancontribute to understand better the mechanism of consciousness and attention, which arebasic and important factors in the cognitive processes. This research will use the greydiscriminate test and expressional chimeric faces (ECF) to explore the attentional biasin USN patients.Methods In study one, the grey discriminant test was conducted on12right-brain-lesioned patients with USN (USN+),12right-brain-lesioned patients withoutUSN (USN-), and20healthy controls (HC). They were matched for age, educationalyears, handedness and mini-mental state examination (MMSE) scores. The comparisonof the attentional deviation scores between the three groups were conducted. In studytwo,12USN patients and30matched healthy controls (HC) were recruited in thisresearch. Both groups were performed with happy-and sad-neutral ECF, and thecomparison of the attentional deviation scores were conducted between and withingroups.Results In study one, differences in scores of USN tests between the three groups weresignificant (Albert test: HC group0.00±0.00, USN-group0.00±0.00, USN+group-0.56±0.39, F(2,41)=33.708, P<0.001; line bisection test: HC group-0.02±0.04, USN- group0.03±0.04, USN+group0.28±0.29, F(2,41)=14.527, P<0.001；clock drawing bymemory: HC group0.00±0.00, USN-group0.08±0.29, USN+group3.58±4.03,F(2,41)=12.558, P<0.001；daisy copying：HC group0.00±0.00, USN-group0.13±0.23,USN+group0.83±0.65, F(2,41)=21.621, P<0.001). The overlapped lesion locationsshowed that USN+patients were more associated with lesions in temporal-parietaljunction (TPJ). The attentioanl deviation scores for the HC, USN-, and USN+groupswere-0.28±0.15,0.41±0.12, and0.92±0.11respectively, with significant differences(F(2,41)=334.324，P<0.001). LSD test showed that the USN+group revealed a rightwardbias much more significant than the USN-group (P<0.001). In study two, theattentioanl deviation scores were significant different (sad-neutral ECF: t=12.192,P<0.001; happy-neutral ECF: t=15.550, P<0.001) between the HC group (sad-neutralECF:-0.25±0.17; happy-neutral ECF:-0.31±0.20) and the USN group (sad-neutral ECF:0.50±0.20; happy-neutral ECF:0.78±0.22), with leftward bias in the HC group andrightward bias in the USN group. For the USN group, the magnitude of rightward biasin the happy-neutral ECF condition was much more significant than in the sad-neutralECF condition (t=3.954， P=0.002). however, for the HC group, there were nostatistically differences under sad-and happy-neutral ECF conditions (t=-1.302，P=0.203).Conclusions In study one, the USN patients reveal an significant attentional bias towardthe right side. In study two, USN patients display rightward attentional bias underboth sad-and happy-neutral ECF conditions. However, the magnitude of rightward biasunder the happy-neutral ECF are much more significant. |
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