Expression Of ER And PR In Breast Hyperplasia, Precancerous Lesions And Breast Cancer And The Relationship Between TCM Syndrome Research

Objective: Study on hyperplasia of mammary glands, precancerouslesions of breast cancer, breast cancer occurrence and development of diseaseand changes in laws, analysis of ER, PR in breast hyperplasia, expression inprecancerous lesions of breast cancer and breast cancer, while exploring bothdifferences in expression between difference TCM syndrome types, syndromedifferentiation of traditional Chinese medicine on the treatment of benign andmalignant diseases of the breast provide objective indicators.Research method: Collected from2007to2011Affiliated Hospital ofShandong University of Traditional Chinese Medicine breast thyroid surgerypatient were hospital treatment and this study on the inclusion criteria andexclusion criteria, complete medical history, after general pathologyconfirmed hyperplasia of mammary glands, breast cancer precursor lesionsand breast cancer each30cases. Retrospective analysis of clinical andpathological characteristics, use of immunohistochemical detection ofexpression of ER and PR. TCM of hyperplasia of mammary glands, breastcancer precursor lesions and breast cancer is divided into two types of liver Qiand coagulated phlegm, flushes any disorder, and three types of stagnation ofsputum, phlegm and blood stasis with coagulation, phlegm and blood stasisdrugs in. Analysis on the differences of the expression of various clinical pathological indicators and difference in TCM. And statistical analysis usingstatistical software version SPSS19.0.Results:1. Expression of ER and PR in comparative mammary gland hyperplasiaand breast cancer, premalignant lesions are significant differences (P<0.05).Expression of ER and PR in breast cancer is the highest. The next isprecancerous lesions. The lowest is mammary gland hyperplasia.2. TCMsyndrome of Comparative mammary gland hyperplasia and breast cancer,premalignant lesions are significant differences (P=0.000).Most TCMsyndrome of mammary gland hyperplasia are syndrome of stagnation ofphlegm, phlegm and blood stasis syndrome of knot (100%,30/30). Most TCMsyndrome of precancerous lesions are syndrome of stagnation of phlegm,phlegm and blood stasis syndrome of knot (93.3%,28/30). Most TCMsyndrome of breast cancer are syndrome of phlegm and blood stasis with,phlegm and blood stasis syndrome of poison in (76.7%，23/30).3. Expression of ER in TCM syndrome of mammary gland hyperplasiaand precancerous lesions, breast cancer are significant differences, butexpression of PR are not significant differences.4. The relation of expression of ER and expression of PR in comparativemammary gland hyperplasia and breast cancer, premalignant lesions arerelevance, and associate degrees for medium. Consistency of experience arestatistically significant, but consistency is medium.Conclusion: Most TCM syndrome of mammary gland hyperplasia aresyndrome of stagnation of phlegm. Most TCM syndrome of precancerouslesions are syndrome of stagnation of phlegm, phlegm and blood stasissyndrome of knot. Most TCM syndrome of breast cancer are syndrome ofphlegm and blood stasis with, phlegm and blood stasis syndrome of poison in.In comparative mammary gland hyperplasia and breast cancer, premalignant lesions, condition the heavier, higher the expression of ER and PR. In thecourse of hyperplasia of mammary glands developing into breast cancer, thepositive expression of ER and PR is higher. In the course of diseasedevelopment, the relation of expression of ER and expression of PR arerelevance and consistent. It can be seen, when the when expression forER-positive, positive PR expression than larger, the higher expression ofER-positive rate, the higher expression of PR-positive rate.