| Objective:To analyze the clinicopathological characteristic of malignant mediastinal tumor and to provide evidence for the prevention, early diagnosis and treatment of malignant mediastinal tumor. Based on the variety of malignant mediastinal tumor, this study mainly explore the onset characteristics, age distribution and therapeutic condition of malignant mediastinal tumor acording to the practical stituation of this hospital.Methods:The surgical specimens from157patients of malignant mediastinal tumor who were treated in first hospital of Jilin University from January2004to December2010were collected,then fixed and stained with HE. The pathologic morphology characteristics of all the cases were analyzed and immunohistochemical staining was performed on some of the cases. Comparative retrospective analysis was performed on all the cases and X2test were adopted for statistical analysis.Results:(1)Of the157cases of malignant mediastianl tumor, there were71cases of thymoma (45.2%),52cases of thymic carcinoma (33.1%),15cases of lymphoma (9.6%) and19cases of other malignant tumor (12.1%), including10cases of malignant mesenchymal tumor,6cases of malignant germ cell tumors and3cases of Nenrogenic tumor. The cases of thymic carxinoma included primary tumor and secondary tumor. The data showed that all of the thymomas were primary, and the incidence of which were the highest, then were the metastatic thymic carcinoma. In the comparison of primary and secondary mediastinal tumor, the metastatic tumor account for84.1%(132/157). As the result the incidence of primary tumors is significantly higher than that of the secondary tumors (P<0.05), which indicate that the primary mediastinal tumor are the most.(2) In the157cases of mediastianl tumors, the thymic tumor were overwhelming with an incidence of73.8%(123/157), while the incidence of the non-thymic tumors was21.7%(34/157). The incidence of thymic tumors is significantly higher than that of the non-thymic tumor (P<0.05), which suggests that the thymic tumors are the most tumor in mediastinal tumor.(3) hi all the-cases of mediastinal tumors, the incidence of male patient is61.8%(97/157) and the incidence of female patient is38.2%(60/157). The incidence of the male patient is obviously higher than that of the female patient (P<0.05). In this study, the age of the patient arranged from5months old to80years, and the average age is30to50years. In the comparison of the age, the patients less than or equal to40years of age account for23.6%(37/157) while the patients more than40years of age account for76.4%(120/157). The incidence of the latter is significantly higher than that of the former (P<0.05).To sum up, in our study, the mediastinal tumor easily occurred in the patients older than40and male patients with a male/female ratio of1.6:1.(4) Because of the anatomic structure speciality of the mediastinum, we compared the incidence of anterior, middle and posterior mediastinum. The incidence of anterior, middle and posterior mediastinum is8.9%(14/157),3.2%(5/157) and8.9%(14/157) respectively, Statistical analysis showed there is in the anterior mediastinum with mediastinal, mediastinal difference in after all have statistical significance. While there is no significant difference between the incidence of the posterior mediastinal tumor and the middle mediastnal (P=0.074).Conclusions:(1) Thymic tumor was the most in mediasnnal tumor in our study.(2) The primary tumor was more than the secondary tumor, while the incidence of the secondary tumor had a rising trend.(3) With the increase of age, the incidence of mediastinal tumor showed a rising trend.(4) Mediastinal tumor was much higher than male in female.(5) Compare according to the anatomic structure, Former mediastinal tumor was higher than the incidence of the mediastinal and mediastinum. |
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