| [object]To explore Shaofuzhuyu ointment paste and topical Chinese Herbs and enema treatment in the clinical treatment of blood stasis, chronic pelvic inflammatory disease, developed Xiaozheng scattered convenient, easy to clean and can be mass production of more stable advanced topical formulations.[Method]Made in the topical formulations of Traditional Chinese Medicine under the guidance of pharmaceutical technology the Shaofuzhuyu ointment paste, herbs composed of:angelica, cinnamon, cumin, ginger, Puhuang Wulingzhi, Corydalis, red peony, Chuanxiong, myrrh. Blood stasis in patients with chronic pelvic inflammatory disease,60cases collected in the Hubei University of Chinese Medicine National Medical Hall outpatient treatment group,30cases to give Shaofuzhuyu ointment paste topical below the belly button and after lumbosacral specific Acupoints position, see below, menstrual cramps topical during the stop, and Chinese Herbs, an enema, Oral side of enema party with the basic prescription:iron water chestnut, Chinese angelica, Chuanxiong, peach kernel, safflower, Dan, TPG, Mustard Seed, herb, Coix seed, Plantago, Citrus aurantium, scorpion, do not stay in line, Gui Zhi, Yun Ling, Eucommia, Cistanche, Antlers, pangolin, turtle shell, licorice, disease different addition and subtraction. Control group of30patients given Xiaozheng Powder for the menstrual period stops and topical, and the same Chinese Herbs enema. After20days for a course, a total of three courses, respectively, were observed in the treatment of a treatment after two courses, three courses of patients with clinical symptoms, physical signs, and clinical CA125, erythrocyte sedimentation rate, such as indexes, and use data of SPSS19.0analysis of the results, which judge the difference of the two groups to draw conclusions.[result]1. Shaofuzhuyu ointment paste the stability of the matrix ratio: extract1. Og, dodecane sulfate0.12g, the Vaseline2.2g, Polypropylene plastic0.8g, monoglyceride2. Og, paraffin2.8g, glycerine1.4g.2. Obtained based on clinical symptoms improved data analysis of Shaofuzhuyu ointment paste the treatment group in the course,2courses,3courses of treatment efficiency were:83%,87%,93%; and Xiaozheng scattered in the control group in a course of treatment, the first2cycles,3course of treatment efficiency, respectively,80%,87%,90%. After each course of treatment group and control group compared with no significant difference (P>0.05). Therefore both in improving the symptoms of blood stasis in patients with chronic pelvic inflammatory disease, Chinese medicine, achieved good results in the signs and efficacy, clinical efficacy, no significant difference between the two.3. The two groups of patients after three courses of treatment Shaofuzhuyu cream paste and Xiaozheng scattered with traditional Chinese medicine oral enema efficacy in improving the signs of considerable.4. B-ultrasonic examination results showed that the differences in treatment effect of the treatment and control groups no significant differences, indicating that the ointment paste and eliminate disease in improving the morphological index Shaofuzhuyu bulk effect is also quite.5. groups in the3months after discontinuation relapse rate was no significant difference (P>0.05), can maintain a better therapeutic effect, long-term efficacy considerable.[Conelusion]The Shaofuzhuyu ointment paste not only transdermal absorption, the effect of fast and pollution-free, no need to roast, easy to use, good cohesion and low skin residues, not overflow paste, save for a long time, large amount of drug loading, drug fully dissolveddiff icult to produce allergies, etc., production molding, matrix stability, suitable for long-term treatment and other new features, the while Biba Bu agent in the production process but also pay attention to the full dissolution of the drug in order to achieve uniform absorption of the skin. And Shaofuzhuyu ointment paste and Chinese Herbs, enema triple therapy can improve the clinical symptoms and signs of blood stasis in patients with chronic pelvic inflammatory disease, the treatment effect and Xiaozheng scattered quite, but its use is more convenient, which can expand the scope of the use of the crowd, it can be used as a powerful alternative to Xiaozheng casual treatment of chronic pelvic inflammatory disease. Now inadequacies is the short observation period, include the sample size is not big enough, can not verify the stability the Shaofuzhuyu ointment paste to the large-scale production to meet the clinical needs further experimental design. |
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