Study On Cognitive Impairment In Spinocerebellar Ataxia Type1,2,3,12

Objective: The aim of this study is to assess cognitive function in patients withspinocerebellar ataxia type1,2,3and12(SCA1, SCA2, SCA3andSCA12). Methods:We appraise global cognition in23paitients including SCA1SCA2SCA3and SCA12diagnosed with genetically confirmed and45healthy peoples matching the patients inage, gender, nation, and term of education by using MOCA and MMSE. Theneuropsychological examination focused on testing executive functions, visuo-spatialperception and verbal memory, attention, immediate and delayed word recall, and logicalthinking function and orientation function. The severity of ataxia in each patient wasrated on the International Cooperative Ataxia Rating Scale (ICARS) We evaluate everysubjects,daily activities by means of Activities of Daily Living Scale (ADL). Results:SCA1SCA2SCA3and SCA12all have different degree cognitive impairment. Patientswith SCA1had significantly impaired executive function, visuo-spatial perception, andattention compared to the healthy peoples. The main cognitive disorders such asimmediate and delayed recall, executive function and verbal fluency in patients withSCA2and SCA3were examined, while attention and visuo-spatial function werepreserved. The severity of motor impairment was determined using the internationalcooperative ataxia rating scale (ICARS), which ranged from11to78, then, the mildataxia was3patients, moderate ataxia was11patients, severe ataxia was3patients, andthe most severe was two patient. The scores of activities of daily living scale (ADLS)were ranged20to66. Conclusion: We found mild impairment on attention, visuo-spatialperception and executive function, immediate and delayed memory and verbal fluency inSCA1-3, and it correlate with disease severity rather than age, age at onset and years ofeducation and disease duration. Most of the patients exhibited mild and moderateddepression, especiallySCA3have severe depression than SCA1-2.