The Effect Evaluation Of Cervical Lesion Screening By Cervical Thinprep Cytologic Test And Human Papilloma Virus Detection

Cervical intraepithelial neoplasia reflects the continuous process of development incervical carcinoma. It is a group of cervical precancerous lesions closely related with cervicalcarcinoma, persistent infection of human papilloma virus is the essential condition of cervicalcarcinoma. From HPV infection develope to cervical intraepithelial neoplasia, then to cervicalcancer, in generally, it has taken about10years, and mild cervical intraepithelial neoplasia mayturn back to normal. Cervical cancer is the only malignant tumor that its incidence andmortality can be reduced by medical intervention. Early detection and treatment of cervicalintraepithelial neoplasia is the most important method to prevent cervical cancer. The mainmethods for screening of cervical lesions include in Pap smear, liquid-based cytology test,electronic colposcopy, computer assisted cytology, the histopathological diagnosis and humanpapilloma virus detection. These methods in early screening have their own advantages anddisadvantages, the standard of screening has not been defined.In our study,3400cases patients of cervical thinprep cytologic test have been examed,and228cases which been found abnormal had been undertaken human papilloma virusdetection and pathological examination under colposcopy. The pathological findings as a goldstandard, the results of cytological detection and biopsy were compared and analyzed, and228cases were done HPV genotyping assay in cervical exfoliated cell. Analysis the populationdistribution of23kinds of HPV Gene subtype in the Baotou area and the relationship betweenHPV infection and cervical lesions, aim to find out a screening method which is a reasonableand cheap in clinical. The end of the study, we can draw the following conclusions:1. The screening of cervical lesions using thinprep cytologic test can detect patients ofcervical lesions immediately. The positive rate of thinprep cytologic test is6.7%in this group.The diagnostic accordance rate in HSIL and cervical carcinoma that patients examed by usingTCT and cervical biopsy is90.48%and100.0%respectively.2. Thinprep cytologic test can be used as the preferred method for screening of cervicallesions without missed diagnosis in all patients with high-grade squamous intraepitheliallesions and cervical carcinoma.3. The date from the region of Baotou city, it is the trend of increase gradually which wasthe positive result rate of human papilloma virus with the aggravation of cervical lesions. Inmost cases, HPV infection incidence age ranged from20to29years, followed by50to59years of age. The most common gene subtypes with high-risk in cervical lesions of patients is HPV-16, followed by33,56,58,18. The detection rate of HPV-16rise following with thecervical lesions increased in severity, particularly in patients with cervical cancer, HPV-16occupies obvious advantage. HPV16gene subtypes in multiple infections are extremelycommon, its infection trend to be increased with cervical lesion level increasing. Apart fromcervical cancer, the level of cervical lesions increase, the rate of multiplicity infection of HPVis increasing as well.4. The patients with the positive results of thinprep cytologic test diagnosis need to dofurther HPV test. If HPV test is positive, the biopsy using colposcopy need to be examed,otherwise, the patients with negative result should be followed up according to clinicalconditions.