| Brain functional cortex injury after stroke often leads to brain function mechanism tochange significantly. Today, with the number of stroke patients increasing, studing thebrain network connectivity evolution after stroke, and then exploring the neural plasticmechanisms after cortex damaged have an important significance and clinical value.This theory studied the brain functional reorganization of patients during the acutephase after basal ganglia injure from the network level based on the Granger Causalanalysis. The block design method was adopted, and the bold-fmri datas of healthysubjects and patients after stroke were collected during the finger tapping movements,then the datas were pre-processed by dparsf. After that, the basic statistical analysis wasdone by spm. Finally, time-domain and frequency-domain Granger causality model ofMJLQYM^XZMOJNYX’ LSO ULYNJSYX’ RT[JRJSY-related regions were established, aftertime-series of interest regions extracted by the seed-point.The result showed that the functional regions in right hemisphere were mainlyactivated both in healthy subjects and patients, and cerebellum and SMA were bilateralactivity. Through time-domain Granger causality modeling, we found that the GrangerNLZXLQNY^NTSSJNYNTSX MJY\JJS ULYNJSYX’ RT[JRJSY-related functional regions hadsignificant differences\NYM YMTXJ MJY\JJS MJLQYM^XZMOJNYX’ functional regions, and thenetwork connections were sparse, meanwhile the connection strengths were significantlyweakened. Based on frequency-domain Granger causality modeling, as an effectivecomplement to time-domain Granger causality modeling we found some causality linkschanged between brain functional regions, which were hidden under time-domainGranger causality analysis. |
