Application Analysis Of Nucleoside Analog For Hepatitis B And Pharmaceutical Care Effect Between2009and2011

Objective: To investigate the current situation and developing trend ofanti-viral hepatitis B drugs in First Hospital of Jilin University from2009to2011, to do a comprehensive analysis; evaluate the short-term efficacy of thedrug, together with clinical pharmacist intervention,in order to offer thescientific evidence for recommendation of optimum Treatment programs of theAntiviral therapy. Methods: Anti-viral hepatitis B drugs used in our hospitalwere analyzed statistically in respect of frequency of drug use (DDDs), take ourhospital in-patient as object of study, and choose the patients in the standardaccording to the grouping to give them the corresponding drugs. To record theaminotransferase, the Child-Pugh score, virus variation condition of the patientsafter the12weeks treatment, evaluate the clinical short-term efficacy. Finallythrough the way of questionnaire survey and pharmacy service before and after acomparative analysis of the results, evaluate the clinical pharmacists innucleoside analog impact of rational drug use. Results: The consumption sum ofanti-viral hepatitis B drugs showed an upward trend from2009to2011, DDDsof the drugs ranking of2009were LAM, ADV, ETV and LDT, DDDs of thedrugs ranking of2010and2011were LAM, ETV, ADV and LDT; after12weeks of treatment, the HBV DNA level of four groups(LAM, united LAM andADV, ETV, LDT)have declined, the negative conversion rate of four groupswere50%、60%、60%and53%; the ALT level, AST level and Child-Pughclassification of the patients also has different improvement after the treatment,there was no significant difference between the groups（P＞0．05）. Conclusion:Antiviral drugs in the hepatitis B treatment can improve liver function and delayprogression of disease. LAM has the highest DDDs, which is relevant to itsgood efficacy and low price. Because of the high price of the anti-viral drugs, it causes the economic burden in parts of the patients. On efficacy, ETV、LDT andLAM can suppress HBV DNA replication, which can be used in anti-viraltherapy for high viral load in chronic hepatitis B(CHB); but the effect of ADV isslower, in more cases, it is used with LAM when lamivudine-resistant happens.Data showed that carry out pharmaceutical service is a effective measures ofimprove drug use, not only strengthen the communication between medicineand patient, but also effectively improve the patient to medication compliance.