Natural Drug Radix Acanthopanacis Semticosi Extract Sustained-release Microspheres Research

Objective Adopting natural drug of Radix Acanthopanacis Semticosi extract as main drugs and sodium alginate, CaCl2as main accessories. Studying and exploring Radix Acanthopanacis Semticosi extract sustained-release microspheres. Providing new Radix Acanthopanacis Semticosi extract forms for clinical treatment of acute or chronic liver injury.Methods Firstly, taking sodium alginate, CaCl2as accessories, via optimizing the preparation technology of the Radix Acanthopanacis Semticosi extract sustained-release microspheres using orthogonal test, studying its entrapment rate, drug load and in vitro release behavior. Elucidating its release mechanism. Secondly, characterizing its related physical and chemical properties. Finally, The contents were determined by HPLC method on the quality control method.Meanwhile, studying its swelling capacity and release characteristics in different pH medium.Results Firstly, in the orthogonal test of Radix Acanthopanacis Semticosi extract sustained-release microspheres in vitro pH6.8phosphoric acid buffer solution medium,0.5h totally releases20.10%, while12h may release up to96.12%, refecting some certain sustained-release effect. Secondly, Radix Acanthopanacis Semticosi extract sustained-release microspheres is brown before drying. Its appearance is rounding and regular. Eleutheroside B in Radix Acanthopanacis Semticosi extract sustained-release microspheres for the average content of10.09%, RSD0.60%. Of acanthopanax senticosus extract sodium alginate gel ball swelling capacity and release behavior show that it is pH sensitive. In the pH1.5hydrochloric acid solution, it scarcely releases, while it does so in pH6.8phosphate buffer solution.Conclusion Radix Acanthopanacis Semticosi extract sustained-release microspheres has the slow release property. After oral dosing, it could rapidly reach the therapy consistency. Drug slow release property can be used to sustain therapy consistency and reduce adverse reactions to drug. The preparation technology for simple process, in the design is practical, and its chemical property was stable. Preparation into microspheres can cover up after drug bad smell, facilitate patients take it. Microsphere preparation development, enrich the acanthopanax senticosus extract drug dosage form, and make its in the treatment of acute or chronic diseases such as liver injury has broad preparation development potential and application prospect.