Effects Of The Prophylactic Use Of Fluconazole On Cefoperazone Induced In Intestinal Fungal Multiplication And Translocation In Rat

Objective:To investigate the effects of the prophylactic use of fluconazole on cefoperazone induced in intestinal fungal multiplication and translocation.Methods:30Wistar rats, male or female, were randomly divided into three groups; Cefoperazone sulbactam sodium was used in the rats of each group every day were gained; after the seventh day, normal saline was injected for3days (group A),while fluconazole was used for3days in group B and for5days in group C. intestinal contents, mesenteric, pancreatic, lung tissue and blood of each group were cultured for fungal, and plasma1-3-beta-D glucan was measured.Results:The number of intestinal fungi and plasma1-3-beta-D glucan in group B and group C was significantly decreased (P<0.05) compared with group A; compared with group B, the number of intestinal fungi and plasma1-3-beta-D glucan in group C was significantly reduced (P<0.05), the total number of fungal translocation to the parenteral tissues in group C was significantly reduced than that in group A and B (P<0.05). The multiplication of intestinal fungal was positively correlated with plasma1-3-beta-D glucan level and fungal translocation (r=0.943and0.923), fungal translocation was positively correlated with plasma parenteral1-3-β-D glucan (r=0.998).Conclusion:Prophylactic use of fluconazole can significantly reduce the multiplication and translocation of intestinal fungal and it is more appropriate to use for5days in prophylaxis; it is helped to detecte plasma1-3-beta-D glucan for early diagnosis of deep fungal infections.