Changes And Significance Of Serum Inflammatory In Patients With Progressive Cerebral Infarction

Objective:Stroke has become a global concern and the universality of health problems, cerebral infarction probably accounted for more than70%of stroke disease. Progressive cerebral infarction accounted for approximately20%-40%of the cerebral infarction, high morbidity, high mortality, intractable, prone to medical malpractice.The experiment was to observe dynamic serum Hs-CRP, SAA, and IL-18levels in progressive cerebral infarction disease patients admitted to hospital within14days,and then to study and explore the connection which the three inflammatory cytokines and progressive cerebral infarction disease.We hope the experiment can help to prevent and cure progressive cerebral infarction disease.Materials and MethodsThe study was based on the principle of random sampling to select32progressive cerebral infarction disease patients and31non-progressive brain infarction disease patients from the Third People’s Hospital of Jinan since the January01,2011to May31,2012. they are divided into progressive cerebral infarction group (PCI group) and non-progressive cerebral infarction the group (NPCI group). All patients were admitted to hospital within24hours of onset.They accepted the same basic medication after admission, thrombolytic therapy were excepted. In addition, selected at random in our hospital for physical examination of the vascular risk factors in outpatient row32as the control group. Observe the serum Hs-CRP, SAA, and IL-18levels of the patients on1day,3day,7day and14days after admission,and check the control group for comparison.Serum Hs-CRP was measured by immune nephelometry method, serum SAA and IL-18was measured by enzyme-linked immunosorbent assay method. In PCI group,we determined whether the serum Hs-CRP was correlated with SAA, and IL-18by analysis of Spearson. At the same time, we determined the SSS of all patients at the time of admission, repeated determine on3day and21day, we measured whether the serum Hs-CRP, SAA, and IL-18levels on lday was correlated with the SSS score.Results:1.1.At all time points, serum Hs-CRP, SAA, IL-18in PCI group levels were significantly higher than that of the NPCI and the control group(P<0.01). At、3、7day points, serum Hs-CRP and SAA in NPCI group levels were significantly higher than that of the control group(P<0.01), however,at14day points,there was no significant different.At all time points, serum IL-18in NPCI group levels were significantly higher than that of the control group(P<0.01).2.In PCI group, serum Hs-CRP, SAA presents the same dynamic trend, reached the peak on lday point then gradually decrease,and both levels were positively correlated (r=0.504, P=0.0002), but the trend of serum IL-18was different, reach the peak on3day point then gradually decrease.IL-18and Hs-CRP were no significant correlated(r=0.091, P=0.538).3Serum SAA,Hs-CRP and IL-18levels on lday point were all significant negative correlated with the SSS on3day and2Id.(P<0.05).Conclusion:Acute progressive cerebral infarction in patients with serum Hs-CRP, SAA and IL-18level were significantly higher and showed a dynamic change. Hs-CRP, SAA and IL-18may be involved in progressive cerebral infarction pathological damage, its specific role remains to be further studied. Early in patients with cerebral infarction,high levels of serum Hs-CRP, SAA, IL-18indicates that progressive cerebral infarction would occur, the higher the level of the three, the disease is more severe, the worse the prognosis.It could be a potential strategy that we could choose inflammatory media timely by dynamic detection of serum Hs-CRP, SAA and IL-18levels for prevention and treatment of progressive cerebral infarction.