| Research confirms, type2diabetes mellitus (2type diabetes mellitus T2DM)) andatherosclerosis (atherosclerosis, AS) may be one and the same pathology based on theparallel development of the two diseases.Chronic, subclinical inflammatory responses maybe their common foundation.Interleukin18(Interleukinlg18, IL-18) is a recentlydiscovered with heterogeneous effect of proinflammatory cytokines in inflammatoryreaction chain, In recent years its role more and more get attention.it plays a key role.Interleukin-18may be linked to inflammatory response, type2diabetes andatherosclerosis of a new hot.Interleukin18and tumor necrosis factor may be a (tumornecrosis factor-a TNF-a) participate in type2diabetes and macrovascular complicationsand development.objective1.to observe the concentration change of IL-18, TNF-a in patients with type2diabetesand carotid atherosclerosis2.Discuss the relationship of serum interleukin-18, TNF-a and type2diabetes withcarotid atherosclerosis, in order to achieve the type2diabetic patients with macrovascularcomplications in the early control purposes.3.understanding of serum interleukin-18, TNF-a level changes and the relationshipbetween each factor.Methodsfrom January2011to January2012in Beijing Second Artillery General HospitalInpatients with a diagnosis of type2diabetic patients: a report of125cases.There were64male, female61, age (54.5±10.2) years of age.All the groups of diabetic patients with the2006WHO diagnostic criteria for diabetes mellitus, and to exclude secondary to diabetesand type1diabetes, complications of diabetes and acute complications, blood diseases,autoimmune diseases, malignant tumor history, recent major operation history of trauma, severe liver and kidney dysfunction, pregnant and lactating women.All patients weretreated with diet or oral hypoglycemic therapy, untreated insulin therapy.selected patientswith diabetes mellitus undergoing carotid artery ultrasonography on atherosclerosis (AS)after the judgment standard of the selected T2DM patients were divided into two groups,namely T2DM associated with carotid atherosclerosis (Carotide artery atherosclerosisgroup CAAS group)(group A) and T2DM alone group (group B), course of disease, bloodglucose levels between the two groups had no significant difference, T2DM group andCAAS group (group A), according to the intima media thickness of carotid artery dividedinto0.9≤IMT＜1.1group (A1group),1.1≤IMT＜1.3group (A2group),1.3≤IMT group(A3group), and have no plaque consists of plaque and plaque group.In addition to select58cases of healthy people as control group (group C);1.Statistics for all patients sex, age, smoking status, height, weight, blood pressure(systolic pressure, diastolic pressure), body mass index (massindex, BMI); Determinationof fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC),triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoproteincholesterol (HDL-C); At the same time, the application of enzyme linked immunosorbentassay method for the detection of all study subjects of serum interleukin-18, TNF-a;2.Determination of carotid artery: color Doppler ultrasound detection of carotid arteryintima media thickness (Intima medi thickness, IMT), atherosclerosis, plaque and stenosisformation condition.3.Statistics: using SPSS13.0statistical analysis software.The obtained data, to (x±s),between the two groups were compared with t test, many groups were compared usinganalysis of variance.Two index correlation analysis using linear regression analysis, thecalculation of correlation coefficient.Result1.T2DM with or without CAAS, serum IL-18, TNF-a higher than the control group,the difference was statistically significant (P <0.01)2.T2DM with CAAS group serum IL-18, TNF-a relatively simple T2DM high, thedifference was statistically significant (P <0.01)3.different carotid IMT group serum IL-18, TNF-a: IL-18, TNF-a in A3group higherthan A1group,and A2group, the difference was statistically significant (P <0.05); groupA2compared with group A1, IL-18, TNF-a increasing, the difference was statisticallysignificant (P <0.05).4.with plaque and no plaque of serum L-18, TNF-a: IL-18, TNF-a with plaque levels than the group without plaque concentration is high, the difference was statisticallysignificant (P <0.05).5.for a carotid atherosclerosis plaque is formed as the dependent variable, to the studyof all risk factors as the independent variables, multivariate conditional Logistic regressionanalysis, the results show the duration of diabetes, TG, IL-18, TNF-a were entered into theregression equation (β=0.252, P=0; β=0.954, P=0.005; β=0.063, P=0.033; β=0.053, P=0.043).The duration of diabetes, TG, IL-18, TNF-a as an independent risk factor forcarotid atherosclerosis.Conclusion1.Patients with type2diabetes mellitus serum IL-18, TNF-a levels and the degree ofcarotid artery atherosclerosis closely associated, with disease progression, IL-18, TNF-alevels may for type2diabetic patients with macrovascular disease markers, through thedetection of serum IL-18, TNF-a levels can predict diabetic macrovascular diseaseprogression;2.IL-18, TNF-a concentration and carotid artery IMT value is positively correlated toserum IL-18, TNF-a, prompting the two factors may be involved in the formation ofatherosclerosis and plaque occurrence and development. |
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