Toxic-Pathoiogic Stuty On Cerebral Regions The Matrix Metal Proteinase Ⅱ(Mmps-2) The Clinical Memoir Which Expresses In The Brain Sol Cytoma Lump Body

Objective:In order to inquire into the matrix metal proteinase II (MMPs-2) in brain sol cytoma lump body expression. Even more has been clear about MMPs-2to the extracellular matrix degeneration at in the sol cytoma infiltration and the shift the crucial function, Also the mmps-2expression more obvious,simultaneously provides the reference and the treatment prospect for the now cerebellum sol cytoma clinical treatment which expresses along with the brain sol cytoma malignant degree markup。Methods:With mouse anti-person matrix metal proteinase-2monoclonal antibody (MAB-0244) pair of45example patient:①The normal brain dampens the brain organizes15examples, in which male8examples, the feminine7examples;②The brain sol cytoma patient’s lump body organizes30examples, in which male18examples, the feminine12examples; According to WHO central nervous system tumor classification, In material including hair cell star type cytoma (Pilocytic Astrocytoma)8examples (WHO Grade Ⅰ); Textile fiber star type cytoma (Fibrillar Astrocytoma)7examples (WHO Grade Ⅱ); Split up not good star type cytoma (Anaplastic Astrocytoma)11examples (WHO Grade Ⅲ); Polymorphic sol metrocyte lump (Glioblastoma Multiforme)4examples (WHO Grade Ⅳ)。Carries on the immunity group analysis to it and withdraws mRNA, examines MMP-2in the content and the normal brain organization and the fluid intelligence the mmps-2expression。 Results:The mmps-2protein dyeing mas culine gender appears the yellowish brown pellet for in the cell membrane orthecytoplasm。MMP-2dampens the dissociation in the accidental brain in the brain organization mRNA to have the expression, IHC displays the weak masculine gender。The high rank sol lump group masculine gender expression rate and the expression intensity are higher than the low rank group obviously, the low rank sol lump group is higher than the bruise group obviously。MMP-2expression in mRNA level and protein level consistent。Conclusions:①After the brain organization dampens, MMP-2has the obvious expression。②mmps-2expression and sol lump malignant degree related, possibly becomes the sol lump malignant degree and the prognosis judgment target。...