Clinical Observation Of Ultrasound-guided Percutaneous Implantation¹²⁵I Seeds For Advanced Pancreatic Carcinoma

Objective: this research investigates the treatment and the efficiency ofintroducing ultrasound¹²⁵I seeds at the later-stage pancreatic carcinoma surgery.Methods：this research adopts the method of analysis16case studies oflater-stage pancreatic carcinoma surgery from China-Japan Union Hospital ofJilin University, in which five cases are stage II, seven cases are stage III, andfour cases are Stage IV; two cases are antecedent gastrointestinal or biliaryintestinal bypass, one case is biliary stent implantation, and the other13cases areImplantation of¹²⁵I particles into the tumor. In all the sixteen patients, nine ofthem have low back and abdominal pain. According to the CT scan result plan thedetail pre-operation plan, and define the number and activity of the seeds. Thenumbers of tumor peripheral matching dose are65-160Gy（MPD）. After the fullbody anesthesia through the ultrasound observe the plant of the seeds. Plant theMick equipment and plant the¹²⁵I seeds according to the pre-operation plan.16patients completed the pre-operation plan.Result：after the operation, nine patients have abdominal pain, six of themfully relieved the pain, two of them partially relieved, one of them has notsignificant recover signal, the effective period is1-3days; there are four caseswhich tumor control were significant recovered, three cases are recoveredpartially, six cases are slightly recovered, but the clinical symptoms were relieved; and three cases have not effective results, and the total effective rate is（OR+PR+SD）81.3%.Conclusion: adopt ultrasound¹²⁵I seeds at the later-stage pancreatic cancersurgery can provide high level of doses to better control and treatment.Additionally, this method can provide the advantages of more accuratepositioning, real-time observation, less trauma and low rate of complication.