Effects Of Hypertension On Brain Structure And Function In Patients With Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive impairment of cognitive function and atrophy of cerebral cortex.Mild cognitive impairment is a transitional stage between normal aging and Alzheimer’s disease, With the analysis of cortical thickness changes in patients with mild cognitive impairment,we could understand the development of the disease and help us prevent the disease.This paper mainly studies cortical thickness atrophy in patients with mild cognitive impairment and the cortical thickness and cognitive function differences between people with hypertension and without hypertension.First, based on the population, we investigated longitudinal changes of the cortical thickness of AD and MCI patients. We found that the regions that have atrophies are mainly those in default mode network (DMN) which is considered to be associated with the cognitive function and memory.Secondly,when we study Alzheimer’s disease,hypertension is considered to be an important fator.With the comparison of cortical thickness in the hypertensive population and non-hypertensive population,we found that in the temporal lobe region,the cortical thickness of hypertensive population is significantly thinner.Finally,with the comparison of cognitive scores between Alzheimer’s disease with hypertension and without hypertension,we found that the cognitive function of the hypertensive population has serious deficiencies. This prompt us to realize that reduce the patients" blood pressure is very important in the treatment of Alzheimer’s disease.