Comparative Study Of Hepatocellular Carcinoma On T2~*-and T1-perfusion Weighted Imaging

Objective: To explore the potential clinical application of T2*-PWItechnique in the pre-operation of hepatocellular carcinoma(HCC) bycomparing T2*-PWI with T1-PWI．Materials and Methods: Twenty-one patients with hepatocellularcarcinoma were performed by3.0T MRI, including T2*-PWI and T1-PWIbefore operation. The signal intensity-time curve of hepatic tumor and normalliver tissue were built. Negative enhancement integral(NEI), maximum slopeof decrease(MSD) and positive enhancement integral(PEI）、maximum slopeof increase(MSI) were separately measured, with the perfusion parameterscorresponding pseudo color graphics. Compare with the perfusion images(including TIC images), and with the perfusion parameters of the hepatictumor and normal liver tissue, and analyze the correlation of tumor perfusionparameters between T2*-PWI and T1-PWI.Results: In the21patients, the TIC images of tumor show rapid declineand rapid rise; However, the normal liver parenchyma TIC images show slowdecline and slow rise on T2*-PWI. While on T1-PWI, the tumor TICimages show rapid rise and quick decline; However, the normal liverparenchyma TIC image show slow rise and slow decline. The perfusionparameters of hepatic tumor and normal liver tissue have obvious differenceon T2*-PWI and T1-PWI(P＜0.05), While NEI、MSD had no obviouscorrelations between PEI、MSI(P＞0.05).Conclusion: MR perfusion weighted imaging (PWI) is a safe, simple functional imaging method which can accurately semi-quantitative analysisthe blood perfusion state of hepatic tumor lesions. T2*-PWI and T1-PWI arethe most widely used methods of dynamic enhanced MRI; Whether PWIimage or TIC image, T2*-PWI and T1-PWI can reflect the blood perfusioncharacteristics of hepatocellular carcinoma, but there was no significantcorrelation between the perfusion parameters. T2*-PWI has importantpreoperative evaluation value for hepatocellular carcinoma.