| [Background] Thyroid cancer is clinically one of the most common endocrinium tumor.The p-athogenesis of it is thoutht presently mainly contains:1) ionizing radiation;2) iodine uptake disfunction;3) hereditary factors;4) thyroid autoimmune diseases. Indolent thyroid nodule is the frequent clinical manifestation,while about4%-7%of the normal crowd possess palpable thyroid nodules, accordingly among the thyroid nonmalignant nodules how to select malignant ones seems not so e-asy. The correct preoperative diagnosis can help the surgeons to select surgical cases, thus patients who needn’t surgery will obviate from it is a part of malignant cases that are hard to be suspected to be malignant via clinical examination-s can be found, too. At present, the common preoperative diagnostic methods include:B ultrasound, CT, radionuclide imaging, determination of thyroid immuno-globulins in blood-serum, fine needle aspiration cytology biopsy (FNAB). FNAB is the most valuable one of them, but it has some false negative rate and a section of cases which can’t get final diagnosis yet. In the meanwhile, it belongs to an examination which will spell injure and also can cause local tumors focus of infection diffusion. To avoid the above defects as well as provide help t-o make more reasonable therapeutic perscriptions, we are trying to look for tumor markers which possess high sensitivity and specificity for early diagnosis of thyroid carcinoma. As the rapid development of the molecular biology technology and immunology technology, as well as our unceasingly elevated cognition of thyroid cancer pathogenesis, now we have found a lot of molecular markers that have relationships with the occurrence, development and turnover of thyroid cancer. Related studies have shown that HMGB-1and TSGF express out of tune in a variety of tumors, and have become their molecular markers. However, there is no related report about detecting both the HMGB-1and TSGF expression in thyroid cancer no matter at home or abroad, yet.[Objective] To study the clinical value of diagnosis of thyroid cancer through joint detection of high mobility group box-1protein (HMGB-1) and tumor-specific growth factors (TSGF).[Methods] HMGB-1and TSGF are tested within86patients with pathologically confirmed thyroid cancer,78cases with nodular goiter and69cases of healthy controls, using ELISA kits. The diagnostic value of HMGB-1, TSGF and its correlations with clinicopathologic features in the thyroid cancer group were analyzed.[Results] The level of HMGB-1was significantly higher in thyroid cancer patients than that in nodular goiter and control group (P<0.05). The level of TSGF in thyroid cancer patients was also significantly higher than that in nodular goiter and control group (P<0.05). ROC curve analysis showed that the combined AUC of HMGB-1and TSGF was0.912, which was significantly higher compared with the AUC of HMGB-1(0.887)or TSGF(0.864)(P<0.05). There is no difference between HMGB-1and TSGF. The level of HMGB-1or TSGF in thyroid cancer patients was no significant correlations with clinicopathologic factors (P>0.05).[Conclusion]1.HMGB1in the serum of patients with thyroid cancer were significantly higher than the level in nodular goiter and control group,there are significant differences between them, the indicators maybe the development-promoti- ng factor of thyroid cancer.2. TSGF in the serum of patients with thyroid cancer were significantly higher than the patients in the nodular goiter groups and the control group. What the nodular goiter group was significantly higher than the control group prove that TSGF determine the significance of the diagnosis and prognosis of thyroid cancer.3. ROC curve analysis showed tha the combination of detection is better than independently tested in the diagnosis of thyroid cancer and has higher sensitivity and specificity, The combination of detection of HMGB-1and TSGF contribute to the early diagnosis and differential diagnosis of thyroid cancer. |
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