Clinic Analysis Of A Case Of Primary Diffuse Large B Cell Lymphoma Of Bone With Hemophagocytic Symdrome

Objective:The clinical features, diagnosis, treatment and prognosis of primary diffuse large B cell lymphoma of bone complicated with hemophagocytic syndrome (LAHS).Methods:A retrospective analysis of our hospital in2012August was a case of lymphoma associated hemophagocytic syndrome(LAHS) in patient with clinical data.Results:The patient showed persistent fever, splenomegaly, bone pain, jaundice, liver damage, high serum ferritin, elevated serum lactate dehydrogenase, hypertriglyceridemia, three departments of blood cell reduction, coagulation disorders, hypofibrinogenemia. Peripheral lymph nodes were without obvious enlargement, the primary disease diagnosis was difficult, the first bone pathology revealed necrosis of bone.Lymphoma pathological type was diffuse large B cell lymphoma. Glucocorticoid and gamma globulin treatment of HPS, G-CSF for stimulation of hematopoiesis, application of rituximab combined with platinum and etoposide, use of broad-spectrum antibiotics together with antifungal drugs to control infection and lymphoma, the diseases were controled good and the patient lives up to now.Conclusions:Onset of performance is bone invasion with obvious pain, lymphatic organs showed only splenomegaly, intermittent fever lasted for half a year. It was hard to be diagnosed. The stages of patients showed that the early the diagnosis, the better the prognosis. Rituximab and effective chemotherapy are prerequisites for remission. Long-term fever, splenomegaly, blood cells reduction, liver damage in patients are risk factors for HPS, and wo should get the pathological results as soon as possible.