Expression And Biological Significance Of Proteasome Subunit LMP-2, Survivin And Caspase-3in Missed Abortion Patients

Objective： To investigate biological effects of proteasome subunit LMP-2,survivin and caspase-3in the pathogenesis of missed abortion by studying thecharacteristics and relationship of proteasome subunit LMP-2, survivin and caspase-3inthe placental villi and chorion of missed abortion.Methods：Thirty missed abortion patients were allocated as study group, andthirty with normal pregnancy as controls. Immunohistochemical method was used todetect the expressions of proteasome subunit LMP-2, survivin and caspase-3in theplacental villi and chorion of the two groups. Correlation analysis was made amongthose indexes.Results：Compared with that of the controls, the expression of LMP-2andsurvivin in the study group were significantly lower, while the expression of caspase-3was higher (P<0.05). In the study group, the caspase-3expression was negativelycorrelated with the expression of LMP-2and survivin respectively, and the expressionof LMP-2was found to be positively correlated with surviving (P<0.05).Conclusion：The abnormal expression and relevance of LMP-2, survivin andcaspase-3play an important role in missed abortion.