| Magnetic resonance imaging (MRI) contrast agent is one of the most powerfulimagining techniques in use because it has a good spatial resolution, and has a betterqualitative analysis in diagnoses. Before MRI contrast agent was used in clinicalapplication, it should be security, biocompatibility. In conclusion, we have provided agenerality and facile method for synthesis of nanometer-sized and functional aminegroups magnetic nanoparticles.It is envisioned to designed MRI contrast agents which is acquire a morespecific clinical diagnosis. The thesis explores a simple and effective method forlarge-scale synthesis of water-soluble magnetic nanoparticles. We protected thesurface amino groups, to design of a simple ligand6-(1,3-dioxo isoindoline)hexanoic acid, and then obtained monodisperse and narrow size, magneticnanoparticles in hydrothermal method. We further promoted this approach tosynthesis of a series of magnetic nanoparticles, such as Fe3O4, Mn3O4, MnFe2O4, andGd2O3. Then, we based on this method, to explore the synthesis of magnetic-opticalmulti-functional specific targeting tumor contrast agent. Fluorescent molecules redfluorescence B (RBITC) and specific tumor targeting was molecule folic acid (FA)was modified the surface of materials. In order to explore a suitable method forlarge-scale production of magnetic-optical multi-functional nanoparticles, we tied toinvestigate its magnetic properties, optical properties, toxicity. The experimentalresults confirm that we successfully synthesis superparamagnetic MnFe2O4, Fe3O4,and paramagnetic Mn3O4, it also verified that the magnetic nanopatticles probes wereconjugated with fluorescent dyes RBITC and cancer-cell-specific targeting moietiesFA have potential advantages got future in vivo and clinical applications. |
PDF Full Text Request