Thiourea Bifunctional Catalyst D - A Reaction Research And Marine Natural Products Serinolamide Total Synthesis Of (3) A

This thesis is divided into two chapters. The first chapter summarized small organic molecules catalyzing asymmetric reaction, especially focused on the research progress of thiourea and thiourea bifunctional catalysts (thiourea catalyst for the Strecker reaction, Mannich reaction of Baylis-Hillman reaction, Friedel-Crafts reaction, Michael addition reaction, cycloaddition).Chiral thioureas have developed into a variety of effective organic catalyst catalyzing the addition reaction of nucleophiles to imines, aldehydes, electron-deficient olefins. A Lewis basic group introducing in the intramolecular obtains bifunctional thiourea catalyst. Bifunctional organic catalysts due to the structure of a Lewis acid and Lewis base activation center, can activate the nucleophile and the electrophilic reagent. This kind of catalysts not only has the general advantages of organic catalysts, such as high catalytic activity, easy preparation, less dosage, but also is an efficient, highly selective new catalysts. The experiments test the catalyst I catalyzing asymmetric D-A reaction of a,β-unsaturated enone compounds and β-nitro-ene.The second chapter introduced the synthesis of marine natural product Serinolamide A (3) and summarized the synthetic value of marine natural products. Then we summed up the total synthesis of the same type of natural product Semiplenamides C, D, E.