Juvenile Idiopathic Arthritis, The Change Of Peripheral Blood T Cell Surface Expression Of Cd28 And Significance

Objective:To investigate the CD28in juvenile idiopathic arthritis (JIA) activity and disease resting period, the significance of changes.Methods: Using flow cytometry (FCM) to detect36cases of onset juvenile idiopathic arthritis in children before treatment and stable disease after peripheral blood CD4and CD8T cell surface CD28expression.Results:JIA children with disease activity of peripheral blood CD4T cell CD28expression was significantly lower than in normal controls (P<0.01), CD8T-cell CD28expression was significantly lower than in normal controls (P<0.01); JIA disease activity in children with peripheral blood CD28-expressing CD4T cells was significantly higher than normal controls (P<0.01); JIA children with the disease activity of peripheral blood CD4T cell count was significantly higher than the control, CD8T cells was significantly reduced (P<0.01); JIA children with diseases of resting peripheral blood CD4T cells and the number of CD8T cells with the normal control was no significant difference (P>0.05); JIA children with diseases of resting peripheral blood CD4T cells, CD28expression and CD8T cells, CD28expression and normal controls was no significant difference (P>0.05).Conclusions:â‘ JIA children with the disease activity of CD4T cell CD28expression was significantly reduced, in other words of CD4of CD28-T lymphocytes increased.â‘¡of JIA in children with near normal in the disease resting peripheral blood CD4T cells and CD8T cells, the number of CD28expression was normal, suggesting that the expression level of CD28-can be used as one of the indicators of active disease in JIA.â‘¢of JIA in children with disease activity of CD4T cells were significantly higher than the normal controls, and further description of CD4T cells, CD4CD28-T cell apoptosis obstacles. The continued survival and T-lymphocyte immune activity contributing factor to disease development.