Compound Zhe Bei Particles Reversal Leukemia Drug Resistance Research Were Reviewed

BackgroundLeukemia is one of China’s top ten high incidence of malignant disease, a serious threat to public health. The treatment cycle, repeated rotation of the treatment programs, often leads to multidrug resistance (MDR) phenomenon, reduce the role of drugs on leukemia cells, of which30%-60%of patients with leukemia will develop refractory acute leukemia, a serious impact patient survival and prognosis. How to reverse the multidrug resistance phenomenon has been the focus of hematological study in recent years, research will explore its pathogenesis to treatment, but pathogenesis of multidrug resistance mechanism is complex, interaction, and effective reversal drugs such as verapamil and cyclosporin A, which produce toxic side effects due to the effective dose. The patient is difficult to tolerance toxic side effects that limits the clinical application. Therefore, looking for low toxicity, efficiency, and target a wide range of resistance reversal agents for the treatment of refractory acute leukemia have very important significance.Dongzhimen Hospital Tumor Hematology early1990s, traditional Chinese medicine theory as a guide, look for the reversal of leukemia resistant to traditional Chinese medicine, to explore the feasibility of Chinese medicine treatment of refractory leukemia. Through access to relevant information and basic research, clinical research prepared Fritillaria Thunbergii Bulb Complex Granules (FTBCG) consist of Fritillaria, Chuanxiong, Han Menispermaceae. Single-agent basis of experiments to determine the safe and effective, then the use of randomized, double-blind, multi-center the same period in controlled clinical programs for the clinical observation, the results show FTBCG in combination with chemotherapy clinical remission rate was36.1%,77.8%of the total effective rate Compared with placebo, with statistical significance. Received extensive attent ion in medical research to explore the treatment of refractory acute leukemia, the success of research and development of proprietary Chinese medicines FTBCG. This paper aims to look forward to the development of more effective reversal drugs for the benefit of the majority of patients through reviewing the research and development ideas on the the FTBCG reversal of multidrug resistance of leukemia.Work contentThis paper by finishing nearly30years each physician understanding of the syndrome types of refractory leukemia and from the reversal of leukemia resistant to traditional Chinese medicine and act ive ingredients, analysis of the etiology and pathogenesis of refractory leukemia, and explore the advantage of drug selection of the CFMP, then to sort out the calendar year on R&D CFMP, summed up, to learn and master the CFMP research and development ideas, to lay the foundation for the future in Chinese medicine research.