Switch Into The Markov Model Statin Drugs For Pharmacoeconomics Evaluation Research

OBJECTIVES:The cost-effectiveness analysis of Zhibituo and simvastatin using Markov model was performed for the purpose of choosing a secure and effective therapy for hyperlipemia.METHODS:1.Markov model analysis:Built Markov state transition model to simulate the dynamic changes of the four states(event free,non-fatal myocardial infatction,non-fatal stoke and death) in the hyperlipemia patients who received the Zhibituo or simvastatin treatment.2.We had applied Markov model using Roll back analysis、Markov cohort simulation to project the costs and effectiveness for the hyperlipemia who had been long-term treated with Zhibituo or simvastatin.One way sensitivity analysis was carried out to determine the robustness of this baseline results.RESULTS:Markov model analysis results:The results of cost-effectiveness analysis showed that patients receiving simvastatin cumulative costs and effects were41600yuan and5.97quality-adjusted life years gained.Patients receiving zhibituo cumulative costs and effects were37900yuan and6.063quality-adjusted life years gained and the CER was6247yuan/QALYs. The analysis which used the2011per capita GDP35000yuan as the threshold standard and Zhibituo therapy for incremental analysis showed that Zhibituo was the better treatment. According to the sensitivity analysis, the change of key parameters in the set range did non affect the model results.CONCLUSION:In conclusion, Zhibituo treatment was more economical than simvastatin treatment for hyperlipemia patients.Compared to simvastatin treatment,Zhibituo treatment seemed prolonging the life of hyperlipemia patients.This study could be used as methodology reference of pharmacoeconomics on the hyperlipemia diseases for Chinese pharmacoeconomist.The baseline data about transition probability based on foreign research.So the findings of this study should be re-evaluated as soon as additional evidence becomes available from the clinical and economic studies.