2009 Influenza A (h1n1) Virus Was Compared With The Common Seasonal Flu Virus Infection Cell Efficiency

In April2009, a new strain of influenza virus that transmitted all over the world was detected in Mexico (Novel Swine-origin Influenza A Virus, S-OIV). World Health Organization (WHO) declared the outbreak a pandemic on11June2009.Although the infection was mild for almost individuals, the young and those who underlying such as asthma, diabetes, morbid obesity and pregnancy seem to at great risk of severe disease progression. According to the latest WHO statistics, the virus has killed almost180,000people, approximately4%of the infection ones. The Health Protection Agency (HPA) reported this Swine-origin H1N1may return.The novel swine-origin influenza virus contains genes from human, pig and avian-origin virus, called three viruses reassortant strains. They could easily integrate different gene from several hosts, becoming a mixer contains different viruses. Therefore they could escape from human immunity system easily than seasonal H1N1virus, which is the most important reason that a pandemic outbreaks.We find that the infection efficiency of seasonal H1N1virus was clearly higher than swine-origin H1N1virus in A549cells; however, the infection efficiency of swine-origin H1N1virus was clearly higher than seasonal H1N1virus in H1650cells as infection time increased.