Ring Of Rheological Properties Of Sodium Alginate Spore, The Influence Of The Carrier Drug Microsphere

Because sodium alginate good physical and chemical properties, by widespread application to all walks of life, it can be used as binder, collapse agent and release in medicine spheres carrier material, can strengthen the solution viscosity, improve the suspended solid sex, improve the stability of the drug. But for sodium alginate solution rheological properties of microspheres in medicine and the study of the characteristics of few reports. According to these deficiencies, this paper using pulse electric field equipment generator preparation calcium alginate microspheres, use NDJ-5digital viscometer determination sodium alginate solution viscosity value. First using the viscosity of learning sodium alginate solution rheological properties of the investigation, understanding the different factors on sodium alginate solution of apparent viscosity influence; Secondly they examine different additives on alginate salt solution rheological characteristics influence; Finally using scanning electron microscopy (sem) and biological inverted microscope observation salt alginate microstructure, review solution rheological properties of salt alginate gel structure, the influence of various factors associated structure and the relationship between them. In order to better the sodium alginate for in the production practice provide theoretical and experimental basis, make sodium alginate in production and practice better development and application.The main conclusions are as follows:1、Sodium alginate performance for the solution of non-newtonian fluid characteristics, the viscosity solution with increased; When the solution in acid conditions, sodium alginate the viscosity solution with pH value rise, when solution pH is greater than6.5, sodium alginate solution viscosity of basic remain the same, sodium alginate solution that has a certain resistance to alkaline; Sodium alginate solution is obtained show out briefly behavior; In certain stirring speed, in the early stage, the sodium alginate solution viscosity will have some degree of rise, but with mixed to continue and sodium alginate will continue to lower the viscosity of the; Sodium alginate solution viscosity of temperature dependence in performance with the increase of temperature, sodium alginate solution viscosity decrease gradually as the temperature continue to increase, the range reduced gradually slow; Sodium alginate solution can be in power under the condition of ultrasonic degradation, even in low power, within the scope of the degree of degradation are obvious; Sodium alginate solution as the membrane filter precision of the increased, its water solution viscosity of a certain degree of reduced.2、Different oil relative sodium alginate solution viscosity influence of different, with the increase of oil phase pH, sodium alginate solution viscosity gradually smaller, calcium alginate microsphere in acidic milieu, the club will appear certain contraction, acid, the better the more obvious contraction, when solution in alkaline milieu, calcium alginate microspheres though form is good, but appeared more scattered oil phenomenon; Sodium alginate in solution non-ion surface active agent, the solution of the system can significantly increase the viscosity, along with the increase of the concentration of surface active agent, sodium alginate solution viscosity fluid also with increased; Along with the increase of the content of cyclosporine, sodium alginate the viscosity solution with a certain degree of increase, but not much of the increase.3、Salt alginate microcapsule surface has a porous network structure, make microcapsules have good play fully the characteristics of choice, it is the capsule as creatures of the reactor material foundation; When the solution pH is low, sodium alginate solution will produce precipitation, and even can produce frozen glue; Along with the increase of the solution pH value, sodium alginate terrorists will gradually swelling, molecular edge will gradually fuzzy, sodium alginate solution viscosity value also is met subsequently reduced.