Serum Mirnas In Focal Segmental Glomerular Sclerosis And Expression In Kidney Disease Is Minimal Change Disease Research

Background:minimal change disease(MCD) and focal segmental glomeruloscelerosis(FSGS) were the common pathological types of primary nephrotic syndrome in childhood. Both of the two types were characterized by massive proteinuria and podocyte injury, and have similar clinical presentation, while distinctive prognoses. Currently, we depend on the kidney biopsy to distinguish FSGS from MCD. microRNA (miRNA, miR), post-transcriptional non-code RNA, participate in the process of phyology、development and pathology. miRNA play a critical role in the pathogenesis of renal diseases.Objective:To analyse the serum levels of children with MCD and FSGS, and to study its correlation with the levels of proteinuia.Methods:the serum levels of miR-192、miR-205、miR-200a、miR-200b and miR-141of patients with MCD and FSGS were measured using the real-time fluorescent quantitive PCR(qRT-PCR).Results:The serum levels of miR-192、miR-205、miR-200a、miR-200b and miR-141of FSGS group were obviously higher compared with MCD group and healthy control group. There was no significant difference between the serum levels of MCD group and healthy control group. The serum levels of miR-192and miR-141of patients were positively correlated with the proteinuria.Conclusion:The miR-192、miR-205、miR-200a、miR-200b and miR-141are potential as the biomarker to distinguish FSGS from MCD.