Guangxi Que Rhizoma Anemarrhenae Decoction For Rheumatoid Arthritis (ra) Synovial Tissue Vascular Endothelial Growth Factor Influence Model Rats

Purpose:To bserve Guishao Zhimu decoction induced by collagen soup decoctionof rheumatoid arthritis (CIA) mice vascular endothelial growth factor (VEGF),the paper discusses the influence of the acting targets.Materials and methods:40only female rats health randomly divided intonormal group, the model group, to fluorine milt group, and Guishao Zhimudecoction group, in normal group, other groups Ⅱ mice induced by collagen typeused by CIA model, Guishao Zhimu decoction, to fluorine altogether milt group,made the drug began, for a total of30days.According to the grading evaluationindex of arthritis, pathological observation mice "number ankle blood vessels,immunohistochemical method to detect vascular endothelial growth factorexpression.Results:1. Histopathological observation. Model group articular cavity visible synovialorganization thickening of the arrangement with irregular cell hyperplasia, alarge number of inflammatory cell, Guishao Zhimu decoction articular cavitygroup is the basic normal tissue cells arranged in a small with inflammatorycell, visible synovial with a little rough. To fluorine milt group articularcavity visible light of the synovial hyperplasia organization with a fewinflammatory cell, visible capsule with a little rough edges, did not see thenecrotic tissue. Normal rats, ankle joint chamber clean, no synovial hyperplasia,articular cartilage surface smooth. Guishao Zhimu decoction group and LEFaltogether rats, synovial hyperplasia is not apparent, synovial not seen "bloodvessels in the formation, cartilage and bone destruction erosion, only a verysmall lymphocytic infiltrates.2.Guishao Zhimu decoction to mice arthritis index soup whole observationtreatment group is the visible model group joint comes on number significantly reduced, joint swelling was significantly reduced, skin redness and swelling,erythema not obvious, the joint deformation degree to reduce.Drug group and modelgroup in arthritis index compares have obvious difference(P <0.05).3.Synovial organization VEGF level detection. Guishao Zhimu decoctionaltogether to fluorine milt group all can significantly reduce rheumatoid jointrats increased level of VEGF synovial group (P <0.01).Conclusion: Guishao Zhimu decoction and model group, altogether groupcompared, arthritis index significantly (P <0.05), joint X-ray and pathologicaltip joint synovial damage degree, reduce rat ankle synovial organization VEGFlevel decreased obviously (P <0.01). Guishao Zhimu decoction can reduce RAaltogether rat ankle synovial organization of the rising level of VEGF, thusinhibit joint inflammation, synovial angiogenesis, and to the destruction ofthe bone of rheumatoid arthritis has good curative effect.