| BackgroundAdult onset Still’s disease(AOSD) is a clinically rare autoimmune disease, occurs in young adults, mostly women.the main feature is the long-term high fever, transient rash, arthritis (pain) and white blood cells which significantly higher, multi-systemthe involvement of the clinical syndrome.Its etiology and pathogenesis hasn’t understood yet, and the lack of the specificil lab indexes and diagnostic standards,which is prone to misdiagnosis.AOSD has not unified a treatment programs, individualized and symptomatic medication.The glucocorticoid(GC) is the main drugs for it, most patients require long-tern-GC treatment to control it, osteoporosis and other side effects, but in the process, and reducing the withdrawal process easily lead to recrudesce. Which plus DMARDs for the GC therapy,but the DMARDs damage for the liver and kidney and bone marrow suppression.For the refractory AOSD also using large doses of intravenous gamma globulin treatment and biological agents.However.this method is expensive, its clinical application is bound to be limited.Writing in the traditional Chinese medicine(TCM),there is no the fully corresponds to the disease, from the occurrence and the clinical symptoms shown,many doctors belong mostly to the "warm diseases","Bi Syndrome","Consumption","internal injuries fever" and other areas.In recent years, the awareness the treatment of Chinese medicine for AOSD has made considerable progress,especially in helping smooth Steroid Withdrawal and preventing the GC side effects, even in the process of alternative GC also highlights the advantages of TCM, shorten the course of the disease, and prevent recurrent disease. TCM treatment of this disease clinical syndrome type is complex, the efficacy evaluation standards are not unified, the lack of objective evaluation indicators and other issues, TCM in the diagnosis and treatment of this disease also greatly improve. The research is to explore the Self-made herbal remedy(Qing Zhu Tang) of the efficacy for the treatment of this disease.ObjectiveThis research can preliminary investigate the AOSD patients’ clinical performance patients and lab indexes, and probe the clinical effect observation of self-made herbal remedy, to raise the awareness of the kind disease, reduced misdiagnosis and leak diagnosis rate.It solve the problem of the disease such as difficult to cure and recurrent, and made a science and objective evaluation.It provides an effective treatment method in clinical. Methods30diagnosed AOSD patients were treated with Qing Zhu Tang.All of them were from rheumatology of CACMS Wangjing Hospital.The treatment lasts4weeks.The related items were measured before and after the treatment to observe the alinical efficacy of treating AOSD patients with Qing Zhu Tang.Results Self-made herbal remedy(Qing Zhu Tang) can significantly improve the fever. joint pain, aore throat, rash, fatigue and sweating.And lower the lab indexes such as WBC, ESR, CRP, SF.The efficient rate was90%.The difference between before and after the treatment was statististical significance(P<0.05).ConclusionIt is reliable that self-made herbal remedy(Qing Zhu Tang)of the AOSD’ treatment.Qing Zhu Tang is worthy of further applicating and promoting in clinicl. |