Evidence For Multiregional Evolution Of Modern Humans From Phylogenetically-informative DNAs

A more complete reading of existing data shows that nucleotide diversities are mostly at optimum level maintained by natural selection. From this new perspective, we studied the origins of humans using the1000Genomes and other public data. We observed enrichment of shared SNPs among different populations in fast evolving DNAs. Only non-syn SNPs in slow evolving proteins that are theoretically predicted to be phylogenetically informative show the expected higher genetic diversity for admixed populations in America. We calculated a date for the split of Africans and non-Africans and the first human exit from Africa at2.03and1.82million years ago. Our analysis also provides data for Denisovans and Neanderthals as descendants of interbreeding between San and Iberians and as ancestors of Australian aborigines, thus genetically linking all speakers of the click language. We further clarified the phylogenetic positions of Finns, Mexicans, and the Tyrolean Iceman. This study presents molecular evidence for a unified view of the complex multiregional evolutionary history of modern humans.