Fabrication And Thermoresponsive Studies Of Hybrid Tianium Nanoparticles Grafted With Poly(N-isopropylacrylamide)

Fabrication of hybrid Tiantium Oxide nanoparticles grafted with thermoresponsivepoly（N-isopropylacrylamide）（PNIPAM） by one step or sequential steps procedures ofsynthesis of2-bromoisobutyrate-functionalized titanium dioxide nanoparticles and thesurface-initiated Single electron transfer living radical polymerization （SET-LRP） ofNIPAM from initiator-functionalized titanium nanoparticle. The products weredetermined by TGA, FT-IR, GPC, XPS, SEM and TEM analysis. According to theresults, nanoparticles synthesized by the sequential steps procedure at ambienttemperature for5minutes are used to procede the following test. The hybridTiO₂-PNIPAM nanoparticles has a self-flocculation effect （Removal effency>90%）with rapid response to the temperature and temperature-controlled switching effect onthe degradation of RhodamineB solution.A free radical emulsion polymerization method was used to prepare Poly（N-isopropylacrylamide）-co-Poly （methylMethacrylate）（PNIPAM-co-PMMA）.PNIPAM-co-PMMA nanofibers were then fabricated by electrospinning.PNIPAM-co-PMMA nanofibers film switched from superhydrophilic to hydrophobic.TiO₂-PNIPAM, TiO₂-PNIPAM/PNIPAM-co-PMMA, TiO₂/PNIPAM-co-PMMA,PNIPAM-co-PMMA and TiO₂on the electrochemical response of daunorubicin wasdetected with cyclic voltammetry （CV） study. TiO₂-PNIPAM/PNIPAM-co-PMMA andTiO₂-PNIPAM nanocomposites could efficiently facilitate the binding behavior ofdaunorubicin of DNA and remarkably enhance the detection sensitivity ofdaunorubicin.The enhancement of the TiO₂-PNIPAM,TiO₂-PNIPAM/PNIPAM-co-PMMA nanocomposites on the electrochemical response ofdaunorubicin have temperature sensitivity. According to the cyclic voltammetry （CV）study, when the temperature was above the LCST, the peak current of daunorubicinincreased remarkably.